Effects of Prenatal Irradiation with an Accelerated Heavy-Ion Beam on Postnatal Development in Rats: I. Neurophysiological Alterations
Effects of Prenatal Irradiation with an Accelerated Heavy-Ion Beam on Postnatal Development in Rats: I. Neurophysiological Alterations
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DOI：
10.1667/rr3334.1
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发表时间：
2005-10
期刊：
影响因子：
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通讯作者：
B. Wang;M. Murakami;K. Eguchi-Kasai;K. Nojima;Y. Shang;Kaoru Tanaka;K. Fujita;H. Coffigny;I. Hayata
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文献类型：
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作者：
B. Wang;M. Murakami;K. Eguchi-Kasai;K. Nojima;Y. Shang;Kaoru Tanaka;K. Fujita;H. Coffigny;I. Hayata
王彬，村上，江口葛赛，K.，Nojima，K.，Sang，Y.，Tanaka K.，Fujita，K.，Coffigny，H.和Hayata，I.加速重离子束产前照射对大鼠出生后发育的影响：I.神经生理变化.辐射。决议164,561-566(2005)。本文研究了孕15天孕鼠经13keV/μ~m加速碳离子束照射后对仔鼠神经生理发育的影响。在断奶前检查出现四个生理标记和获得五个反射的年龄。体重的增加被监测，直到后代3个月大。通过两项行为测试来评估成年后的雄性后代。为了进行比较，对相同生物终点估计的X射线的影响进行了研究。对于早期的大多数终点，接受0.1GY加速碳离子或X射线产前照射的后代与假照射的后代相比没有显著变化。然而，所有接受2.5Gy射线照射的后代都在断奶前死亡。与暴露在0.5-2GyX射线照射下的后代相比，接受加速碳离子照射的母鼠的后代通常表现出更高的产前死亡和断奶前死亡率，明显延迟其生理标志和反射的完成，以及体重的增加。在此剂量范围内，出生后30、60和90日龄的主要器官重量与体重的比率也显著降低。结果表明，在妊娠第15天，0.5-2Gy射线照射会引起子代永久性改变，并呈剂量依赖关系。这些变化包括永久性生长迟缓，主要器官的形态畸形，包括小头畸形，反射能力降低，生理标志的出现延迟，以及成人行为的改变。暴露在1到2GY的辐射下会导致生长迟缓和行为改变，这种改变会持续终生。加速的碳离子通常比X射线引起更多的有害影响。
Abstract Wang, B., Murakami, M., Eguchi-Kasai, K., Nojima, K., Shang, Y., Tanaka K., Fujita, K., Coffigny, H. and Hayata, I. Effects of Prenatal Irradiation with an Accelerated Heavy-Ion Beam on Postnatal Development in Rats: I. Neurophysiological Alterations. Radiat. Res. 164, 561–566 (2005). Effects on postnatal neurophysiological development in offspring were studied after exposure of pregnant Wistar rats to accelerated carbon-ion beams with an LET of about 13 keV/ μm at doses ranging from 0.1 Gy to 2.5 Gy on the 15th day of gestation. The age at which four physiological markers appeared and five reflexes were acquired was examined prior to weaning. Gain in body weight was monitored until the offspring were 3 months old. Male offspring were evaluated as young adults using two behavioral tests. The effects of X rays estimated for the same biological end points were studied for comparison. For most of the end points at early age, no significant alterations were observed in offspring that received prenatal irradiation with 0.1 Gy of either accelerated carbon ions or X rays compared to the offspring of sham-irradiated dams. However, all offspring whose dams received 2.5 Gy died prior to weaning. Offspring from dams irradiated with accelerated carbon ions generally showed higher incidences of prenatal death and preweaning mortality, markedly delayed accomplishment in their physiological markers and reflexes, and gain in body weight compared to those exposed to X rays at doses of 0.5 to 2 Gy. Significantly reduced ratios of main organ weight to body weight at the postnatal ages of 30, 60 and 90 days were also observed within this dose range. The results indicate that irradiation with 0.5 to 2 Gy on day 15 of gestation caused permanent alterations in offspring that were dependent on dose. The alterations include permanent growth retardation, morphological malformations in main organs, including microcephaly, diminished reflex attainment, delayed appearance of physiological markers, and changes in adult behavior. Exposure to 1 to 2 Gy of radiation resulted in growth retardation and behavioral alterations that persisted throughout life. Accelerated carbon ions generally induced more detrimental effects than X rays.