Comparison of Sensitization to Ambulation‐increasing Effects of Cocaine and Methamphetamine after Repeated Administration in Mice
Comparison of Sensitization to Ambulation‐increasing Effects of Cocaine and Methamphetamine after Repeated Administration in Mice
复制标题
小鼠重复给药后可卡因和甲基苯丙胺对增加行走的敏感性的比较
DOI：
10.1111/j.2042-7158.1991.tb03188.x
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发表时间：
1991
影响因子：
3.3
通讯作者：
S. Tadokoro
中科院分区：
文献类型：
--
作者：
M. Hirabayashi;S. Okada;S. Tadokoro
摘要：在单独放入倾斜活动笼中的小鼠中，比较了以3-4天间隔重复（5次）皮下注射可卡因（10、20或40 mg kg−1）和甲基苯丙胺（1、2或4 mg kg−1）的效果。每次给药后3-4 h观察到安培增加效应的进行性增强，表明发生了致敏作用。两种药物的发生率和产生致敏作用的最佳剂量相似。然而，可卡因后的效果增强进展迅速，最大致敏早于甲基苯丙胺给药后观察到。此外，较高剂量的可卡因（40 mg kg−1）引起了与短暂惊厥前体征同时出现的刻板症状，连续给药后这些症状得到了加强。相比之下，甲基苯丙胺引起了更渐进的增强，但高剂量（4 mg kg−1）产生了无惊厥前体征的刻板反应。相应的，增强发展的有效剂量表明，可卡因是比甲基苯丙胺在产生致敏作用的效力。两种药物之间发生交叉致敏反应。因此，可卡因的致敏作用与甲基苯丙胺不同，这是由于其致敏速度、强度以及是否存在惊厥前变化的差异。
Abstract— The effects of repeated (5 times) subcutaneous administration of cocaine (10, 20 or 40 mg kg−1) and methamphetamine (1, 2 or 4 mg kg−1) at 3–4 day intervals have been compared in mice placed individually into tilting activity cages. A progressive enhancement of the ambulation‐increasing effect was noted for 3–4 h after each administration, indicating that sensitization occurred. This occurrence and the existence of an optimal dose producing sensitization were similar for both drugs. However, enhancement of the effect after cocaine progressed rapidly and maximum sensitization was observed earlier than after methamphetamine administration. Moreover, the higher doses of cocaine (40 mg kg−1) caused stereotypies concurrent with preconvulsive signs of short duration that were enhanced by serial administration. In contrast, methamphetamine caused a more progressive enhancement, but stereotypies with no preconvulsive signs were produced by the higher dose (4 mg kg−1). The respective, effective doses for the development of enhancement suggested that cocaine was less potent than methamphetamine in producing sensitization. Cross‐sensitization occurred between both drugs. Thus, sensitization to cocaine was distinct from that to methamphetamine due to differences in its rapidity, intensity, and the presence or absence of preconvulsive changes.
影响因子：
21.1
作者：
C. Johanson;M. Fischman
通讯作者：
C. Johanson;M. Fischman