Functionalized mesoporous silica nanoparticles templated by pyridinium ionic liquid for hydrophilic and hydrophobic drug release application
Functionalized mesoporous silica nanoparticles templated by pyridinium ionic liquid for hydrophilic and hydrophobic drug release application
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DOI：
10.1016/j.jscs.2020.01.003
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发表时间：
2020-03
影响因子：
5.6
通讯作者：
N. S. Zaharudin;E. D. Mohamed Isa;H. Ahmad;M. B. Abdul Rahman;K. Jumbri
中科院分区：
文献类型：
--
作者：
N. S. Zaharudin;E. D. Mohamed Isa;H. Ahmad;M. B. Abdul Rahman;K. Jumbri
化疗是所有癌症患者最常见的治疗方法，但由于缺乏药物的选择性，这种治疗会带来许多副作用。为了克服这个问题，使用更好，更有效的交付代理是解决方案。介孔二氧化硅纳米粒是一种新型的药物载体。这是由于其理想的性能，如可调孔，大表面积，良好的生物相容性和易于功能化。此外，这些性质可以通过利用替代模板剂如吡啶离子液体来调节。此外，通过采用表面功能化，MSN作为药物递送剂的有效性也可以增加。以溴化十六烷基吡啶离子液体为模板制备MSNs，并通过后接枝法对MSNs进行表面功能化，分别得到MSN-NH_2、MSN-SH和MSN-COOH作为药物载体。然后将这些功能化的MSN用于亲水性药物吉西他滨和疏水性药物槲皮素的载药和药物释放研究。对于槲皮素，MSN-NH 2的载药量最高（72%），48 h释放最慢（14%）;对于吉西他滨，MSN-COOH的载药量最高（45%），48 h释放最慢（15%）。基于这些结果，可以认为具有表面功能化的介孔二氧化硅纳米颗粒具有适合于控制药物释放的性质，其在一段时间内提供恒定的释放行为，以避免重复给药，其中药物以固定的剂量和规律的时间间隔给药。
Chemotherapy is the most common treatment for all cancer patients but this treatment poses many side effects due to lack of drug’s selectivity. To overcome this problem, utilizing a better and more effective delivery agent is the solution. Mesoporous silica nanoparticles (MSNs) emerged as a promising platform in development of drug delivery agent. This is due to its desirable properties such as tunable pores, large surface area, good biocompatibility and easy functionalization. Furthermore, these properties can be tuned through the utilization of alternative template such as pyridinium ionic liquid. Besides, by employing surface functionalization, the effectiveness of MSNs as drug delivery agent may also increase. This work reported the usage of 1-hexadecylpyridinium bromide ionic liquid as template for MSNs production and the surface of MSNs was then further functionalized via post – grafting method in order to obtain MSN – NH2, MSN – SH and MSN – COOH as drug carrier, respectively. These functionalized MSNs were then used to study the drug loading and drug release of hydrophilic drug, gemcitabine and hydrophobic drug, quercetin. For quercetin, MSN-NH2had the highest drug loading percentage (72%) and slowest release (14%) in 48 h while for gemcitabine, it was found that MSN-COOH had the highest drug loading percentage (45%) and slowest release (15%) in 48 h. Based on the results, it is suggested that mesoporous silica nanoparticle with surface functionalization has suitable properties for controlled drug release which gives constant release behavior over a period of time to avoid repeated administration of drug where the drug is administered at a fixed dosage and regular time interval.