Magnetically Aligned Nanorods in Alginate Capsules (MANiACs): Soft Matter Tumbling Robots for Manipulation and Drug Delivery
Magnetically Aligned Nanorods in Alginate Capsules (MANiACs): Soft Matter Tumbling Robots for Manipulation and Drug Delivery
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DOI：
10.3390/mi10040230
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发表时间：
2019-04-01
期刊：
影响因子：
3.4
通讯作者：
Cappelleri, David J.
中科院分区：
文献类型：
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作者：
Mair, Lamar O.;Chowdhury, Sagar;Cappelleri, David J.
目前正在开发由生物兼容材料组成的柔软、不受束缚的微型机器人，用于在芯片实验室和医疗场景中完成微操作和药物输送任务。海藻酸盐具有良好的生物相容性、生物降解性和药物包封性，在医用微型机器人领域具有巨大的应用潜力。在这里，我们描述了在海藻酸盐胶囊中合成MANiAC磁定向纳米棒，用于作为不受束缚的微机器人表面翻转器，通过旋转磁场演示磁引导的横向翻滚。疯狂的平移在组织表面和倾斜的斜坡上都有表现。这些藻酸盐微型机器人能够在毫米级距离内操纵物体。最后，我们演示了狂人在平移翻滚运动中的有效载荷释放能力。
Soft, untethered microrobots composed of biocompatible materials for completing micromanipulation and drug delivery tasks in lab-on-a-chip and medical scenarios are currently being developed. Alginate holds significant potential in medical microrobotics due to its biocompatibility, biodegradability, and drug encapsulation capabilities. Here, we describe the synthesis of MANiACsMagnetically Aligned Nanorods in Alginate Capsulesfor use as untethered microrobotic surface tumblers, demonstrating magnetically guided lateral tumbling via rotating magnetic fields. MANiAC translation is demonstrated on tissue surfaces as well as inclined slopes. These alginate microrobots are capable of manipulating objects over millimeter-scale distances. Finally, we demonstrate payload release capabilities of MANiACs during translational tumbling motion.