Increasing walking and bright light exposure to improve sleep in community-dwelling persons with Alzheimer's disease: results of a randomized, controlled trial.
Increasing walking and bright light exposure to improve sleep in community-dwelling persons with Alzheimer's disease: results of a randomized, controlled trial.
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DOI：
10.1111/j.1532-5415.2011.03519.x
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发表时间：
2011-08
影响因子：
6.3
通讯作者：
Teri L
中科院分区：
文献类型：
--
作者：
McCurry SM;Pike KC;Vitiello MV;Logsdon RG;Larson EB;Teri L
测试步行、光照和组合干预（步行加光照加睡眠教育）对阿尔茨海默病 (AD) 患者睡眠的影响。由盲法评估员进行的随机对照试验。独立的社区生活。 132 名 AD 患者及其家庭护理人员。参与者被随机分配接受三种主动治疗（步行、轻度、联合治疗）或接触控制中的一种。参与者接受了三到六次家访。主要结果是基于手腕活动记录仪的患者总唤醒时间，以及护理人员根据睡眠障碍清单（SDI）对患者睡眠质量的评分。次要睡眠结果包括患者睡眠百分比、觉醒次数和总睡眠时间的额外活动记录测量。与对照组相比，步行 (p<.05)、轻度治疗 (p<.04) 和联合治疗 (p<.01) 的患者在测试后的总唤醒时间有显着改善（效果大小 0.51 – 0.63），但 SDI 没有显着改善。在积极治疗的受试者中也观察到活动记录睡眠百分比的适度效果大小改善。积极治疗组之间没有显着差异，六个月时任何睡眠结果也没有组间差异。与遵守步行和光照建议的患者相比，遵守步行和光照建议的患者（每周 4 天以上）的总唤醒时间显着减少（p<.05），并且测试后的睡眠效率更高。步行、光照及其组合可能是改善社区 AD 患者睡眠的有效治疗方法，但需要始终坚持治疗建议。
To test the effects of walking, light exposure, and a combination intervention (walking plus light plus sleep education) on the sleep of persons with Alzheimer’s disease (AD). Randomized, controlled trial with blinded assessors. Independent community living. 132 AD patients and their in-home caregivers. Participants were randomly assigned to one of three active treatments (walking, light, combination treatment) or contact control. Participants received three or six in-home visits. Primary outcomes were patient total wake time based on wrist actigraphy, and caregiver ratings of patient sleep quality on the Sleep Disorders Inventory (SDI). Secondary sleep outcomes included additional actigraphic measurements of patient sleep percent, number of awakenings, and total sleep time. Patients in walking (p<.05), light (p<.04), and combination treatment (p<.01) had significant improvements in total wake time at post-test (effect size 0.51 – 0.63) compared to control subjects, but no significant improvement on the SDI. Moderate effect size improvements in actigraphic sleep percent were also observed in active treatment subjects. There were no significant differences between active treatment groups, and no group differences for any sleep outcomes at six months. Patients with greater adherence (4+ days/week) to walking and light exposure recommendations had significantly (p<.05) less total wake time and better sleep efficiency at post-test than those with lesser adherence. Walking, light exposure and the combination are potentially effective treatments for improving sleep in community-dwelling persons with AD, but consistent adherence to treatment recommendations is required.
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影响因子：
5.6
作者：
DOUGLASS, AB;BORNSTEIN, R;DEMENT, WC
通讯作者：
DEMENT, WC
DOI：
10.1111/j.1532-5415.1999.tb03833.x
发表时间：
1999-07-01
影响因子：
6.3
作者：
Alessi, CA;Yoon, EJ;Cruise, PA
通讯作者：
Cruise, PA
影响因子：
3.3
作者：
Paniagua, Miguel A.;Paniagua, Elizabeth W.
通讯作者：
Paniagua, Elizabeth W.
DOI：
10.1177/1533317510376173
发表时间：
2010-09
期刊：
American journal of Alzheimer's disease and other dementias
影响因子：
--
作者：
McCurry SM;Pike KC;Logsdon RG;Vitiello MV;Larson EB;Teri L
通讯作者：
Teri L
影响因子：
10.6
作者：
ALEXOPOULOS, GS;ABRAMS, RC;SHAMOIAN, CA
通讯作者：
SHAMOIAN, CA