ABNORMAL REGULATION OF IGG PRODUCTION IN MULTIPLE-SCLEROSIS
ABNORMAL REGULATION OF IGG PRODUCTION IN MULTIPLE-SCLEROSIS
复制标题
DOI：
10.1212/wnl.32.3.228
复制
发表时间：
1982-01-01
期刊：
影响因子：
9.9
通讯作者：
ARNAUD, P
中科院分区：
文献类型：
--
作者：
GOUST, JM;HOGAN, EL;ARNAUD, P
在用美洲商陆有丝分裂原 (PWM) 刺激后，活动性多发性硬化症 (MS) 患者的外周血单核细胞 (MNC) 产生的 IgG (8595 ng/ml，P < 0.01) 明显多于正常年龄匹配对照的 MNC (5477 ng/ml)；那些在稳定期进行测试的人产生的 IgG 较少（4076 ng/ml，P < 0.01）。用高碘酸钠 (SP) 治疗 MNC，在正常对照和大多数稳定 MS 患者中产生了 PWM 驱动的 IgG 产生的抑制细胞，但只有 26% 的活动性疾病患者中产生了 IgG 产生增加的抑制细胞。这表明诱导型抑制性 T 细胞的缺陷与对多克隆激活的超正常 B 细胞反应相关。在活动期从多发性硬化症患者获得的 T 淋巴细胞强烈抑制正常 B 淋巴细胞产生 IgG，而在正常 T 细胞存在的情况下，他们的 B 细胞通常会产生更多的 IgG。在活动性多发性硬化症中，B 细胞对激活的抑制性 T 细胞的相对无反应会使辅助信号不平衡，导致 B 细胞激活增加，这可能会耗尽用于 IgG 产生的诱导性抑制细胞库。
After stimulation with pokeweed mitogen (PWM), peripheral blood mononuclear cells (MNC) from patients with active multiple sclerosis (MS) produced significantly more IgG (8595 ng/ml, P < 0.01) than MNC from normal age-matched controls (5477 ng/ml); those tested during stable periods produced less IgG (4076 ng/ml, P < 0.01). Treatment of MNC with sodium periodate (SP) generated suppressor cells for PWM-driven IgG production in normal controls and in most of the stable MS patients, but, in only 26%, of patients with the active disease, in whom an increase in IgG production was often seen. This suggests a deficiency of inducible suppressor T cells associated with a supranormal B-cell response to polyclonal activation. T lymphocytes obtained from MS patients during active episodes strongly suppressed IgG production by normal B lymphocytes, whereas their B cells often produced more IgG in the presence of normal T cells. In active MS, a relative B-cell unresponsiveness to activated suppressor T cells would leave helper signals unbalanced, leading to increased B-cell activation which might deplete the pool of inducible suppressor cells for IgG production.