Dementia Therapy Targeting Tau
Dementia Therapy Targeting Tau
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DOI：
10.1007/978-981-32-9358-8_30
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发表时间：
2019-01-01
期刊：
影响因子：
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通讯作者：
Buee, Luc
中科院分区：
文献类型：
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作者：
Buee, Luc
Tau是一种微管相关的tau蛋白，但它也具有非微管功能。它聚集在阿尔茨海默病和许多称为tau蛋白病的神经退行性疾病中。这种聚集可能是由于tau蛋白基因突变，MAPT，在选择性剪接，翻译后修饰或truncation.This的失调最后一章地址周围的tau蛋白及其基因，MAPT的治疗潜力的各种研究。许多治疗策略正在进行中，但由于缺乏对tau生理功能的了解而受到阻碍。
Tau is a microtubule-associated tau proteins but it has also non-microtubular functions. It aggregates in Alzheimer’s disease and many neurodegenerative disorders referred to as tauopathies. Such aggregation may result from mutations on the tau gene, MAPT, dysregulation in alternative splicing, post-translational modifications or truncation. This final chapter addresses some of the various researches on a therapeutic potential around the tau protein and its gene, MAPT. Many therapeutic strategies are ongoing but they are hampered by the lack of knowledge on tau physiological functions.