Clinical application of ET-Kyoto solution for lung transplantation
Clinical application of ET-Kyoto solution for lung transplantation
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DOI：
10.1007/s00595-014-0918-0
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发表时间：
2015-04-01
期刊：
影响因子：
2.5
通讯作者：
Date, Hiroshi
中科院分区：
文献类型：
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作者：
Ikeda, Masaki;Bando, Toru;Date, Hiroshi
由于日本严重的供体短缺，即使在2010年修改《器官移植法》后，日本的扩展标准肺回收频率也有所增加。我们开发了一种新的肺保存解决方案，“ET京都解决方案”，以加强肺保存，以尽量减少原发性移植物功能障碍（PGD），并改善移植后的结果。在这项研究中，我们回顾性分析了我们的结果，肺移植使用ET京都解决方案。从2002年到2012年，26名患者接受了脑死亡供体的ET-京都溶液保存的肺移植。我们回顾性分析了移植后肺功能和长期生存率。通过PGD分级系统评估移植物性能。移植肾平均缺血时间为483.8 ± 19.0 min，尽管缺血时间较长，但再灌注后氧合能力和呼吸功能恢复均可以接受。移植后5年生存率为85.1%。ET-Kyoto保存液保存的肺尽管保存时间较长，但术后肺功能良好，长期存活率高。对于缺血时间较长的移植物，结果是可以接受的。
Because of the severe donor shortage in Japan, even after the revision of the Organ Transplant Law in 2010, the frequency of recovery of extended criteria lungs has increased in Japan. We developed a new lung preservation solution, "ET-Kyoto solution," to enhance lung preservation, to minimize primary graft dysfunction (PGD) and to improve the post-transplant outcomes. In this study, we retrospectively analyzed our results of lung transplantation using the ET-Kyoto solution. From 2002 to 2012, 26 patients underwent transplantation of lungs preserved with ET-Kyoto solution from brain-dead donors. We retrospectively reviewed the post-transplant pulmonary function and long-term survival. The graft performance was assessed by the PGD grading system. The mean graft ischemic time was 483.8 +/- A 19.0 min. The oxygenation capacity after reperfusion and recovery of respiratory function were both acceptable despite the long ischemic time. The survival rate at 5 years after transplantation was 85.1 %. Lungs preserved by ET-Kyoto solution had satisfactory postoperative lung function, despite the long preservation time, with excellent long-term survival. The results were acceptable for the use of grafts with a long ischemic time.