Synthesis of novel oxime-containing pyrazole derivatives and discovery of regulators for apoptosis and autophagy in A549 lung cancer cells
Synthesis of novel oxime-containing pyrazole derivatives and discovery of regulators for apoptosis and autophagy in A549 lung cancer cells
复制标题
新型含肟吡唑衍生物的合成及A549肺癌细胞凋亡和自噬调节因子的发现
DOI：
10.1016/j.bmcl.2010.06.121
复制
发表时间：
2010-08-15
影响因子：
2.7
通讯作者：
Miao, Jun-Ying
中科院分区：
文献类型：
--
作者：
Zheng, Liang-Wen;Li, Ying;Miao, Jun-Ying
以3-苯基-1-吡唑-5-羧酸乙酯为原料，与2-溴-1-苯乙烷酮反应，再与盐酸羟胺反应，合成了一系列新型含肟吡唑衍生物。通过IR、(1)H NMR、HRMS和x射线分析对其结构进行了表征。复合治疗对A549肺癌细胞增殖有剂量和时间依赖性的抑制作用。抑制生长的主要原因是诱导自噬。(C) 2010 Elsevier Ltd.版权所有。
A series of novel oxime-containing pyrazole derivatives were synthesized by the reaction of ethyl 3-phenyl-1H-pyrazole-5-carboxylate derivatives and 2-bromo-1-phenylethanone followed by the reaction with hydroxylamine hydrochloride. The structures were determined by IR, (1)H NMR, HRMS, and X-ray analysis. A dose-and time-dependent inhibition of proliferation was observed in A549 lung cancer cell after compound treatment. Inhibition of growth was mainly attributed to the autophagy induction. (C) 2010 Elsevier Ltd. All rights reserved.