Nanoscale detection of metal-labeled copolymers in patchy polymersomes
Nanoscale detection of metal-labeled copolymers in patchy polymersomes
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DOI：
10.1039/c4py01508h
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发表时间：
2015-03
影响因子：
4.6
通讯作者：
Lorena Ruiz-Pérez;J. Madsen;Efrosyni Themistou;J. Gaitzsch;Le Messager;S. Armes;G. Battaglia
中科院分区：
文献类型：
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作者：
Lorena Ruiz-Pérez;J. Madsen;Efrosyni Themistou;J. Gaitzsch;Le Messager;S. Armes;G. Battaglia
我们报告的聚合物形成的嵌段共聚物的合成使用两种不同的合成路线的基础上原子转移自由基聚合（ATRP）和可逆加成断裂链转移（RAFT）聚合，分别。用1，4，7，10-四氮杂环十二烷-1，4，7，10-四乙酸（DOTA）官能化允许嵌段共聚物链用电子致密金属离子（例如铟）标记。所得到的金属共轭共聚物可以通过具有单链分辨率的透射电子显微镜来可视化，从而使得能够在纳米尺度上研究聚合物/聚合物的不溶性和相分离。
We report the synthesis of polymersome-forming block copolymers using two different synthetic routes based on Atom Transfer Radical Polymerization (ATRP) and Reversible Addition Fragmentation chain Transfer (RAFT) polymerization, respectively. Functionalization with 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) allowed the block copolymer chains to be labelled with electron-dense metal ions (e.g. indium). The resulting metal-conjugated copolymers can be visualized by transmission electron microscopy with single chain resolution, hence enabling the study of polymer/polymer immiscibility and phase separation on the nano-scale.