Genomic screen for substance dependence and body mass index in southwest California Indians
Genomic screen for substance dependence and body mass index in southwest California Indians
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DOI：
10.1111/j.1601-183x.2006.00246.x
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发表时间：
2007-03-01
影响因子：
2.5
通讯作者：
Wilhelmsen, Kirk C.
中科院分区：
文献类型：
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作者：
Ehlers, Cindy L.;Wilhelmsen, Kirk C.
药物滥用和肥胖是健康差距，可能比其他一些种族群体更折磨美洲原住民。关于土著人的一个理论假设是，长期依赖觅食和自给农业的历史可能导致了改善遗传适应性的性状的选择性富集，即所谓的“节俭”或“脂肪节省”基因。我们推测，同样的选择压力可能会丰富遗传变异，增加饮酒和滥用药物的风险。在这里，我们报告了基因组扫描的结果，比较了两种消费表型的结果：“任何药物依赖和/或经常使用烟草”和体重指数（BMI）在西南加州（SWC）印度家庭。使用来自SOLAR的方差分量分析生成比值比（LOD）评分的对数。在6号染色体上发现了“任何药物”（LOD评分= 3.3）和BMI（LOD评分= 2.3）表型的连锁证据。两种表型的双变量分析显示，该位置的合并LOD评分为4.1。在染色体6、15、16和21上发现了“任何药物”表型的其他位点，在染色体8、16和18上发现了BMI的其他位点（LOD评分范围在1.2和2.3之间）。这些结果提供了暗示性的证据，在这个使命印度人口的药物滥用和BMI的联系，此外，提供初步数据表明，“消费表型”可能会分享一些遗传决定因素。
Substance abuse and obesity are health disparities that may afflict Native Americans more than some other ethnic groups. One theoretical assumption concerning Native people is that the long history of dependence on foraging and subsistence agriculture may have led to selective enrichment of traits that improve genetic fitness, so called 'thrifty' or 'fat sparing' genes. We have speculated that this same selective pressure may have enriched for genetic variants that increase the risk for consumption of alcohol and drugs of abuse. Here, we report the results of a genome scan that compared findings for two consumption phenotypes: 'any drug dependence and/or regular tobacco use' and body mass index (BMI) in southwest California (SWC) Indian families. Variance component analyses from SOLAR were used to generate log of the odds ratio (LOD) scores. Evidence for linkage was found on chromosome 6 for both the 'any drug' (LOD score = 3.3) and BMI (LOD score = 2.3) phenotypes. Bivariate analyses of the two phenotypes revealed a combined LOD score of 4.1 at that location. Additional loci on chromosomes 6, 15, 16 and 21 were found for the 'any drug' phenotype, and on chromosomes 8, 16 and 18 for BMI (LOD scores ranged between 1.2 and 2.3). These results provide suggestive evidence for linkage for substance abuse and BMI in this Mission Indian population and, furthermore, provide preliminary data suggesting that 'consumption phenotypes' may share some genetic determinants.