Cardiac Dysfunction Assessed by Echocardiographic Tissue Doppler Imaging Is an Independent Predictor of Mortality in the General Population
Cardiac Dysfunction Assessed by Echocardiographic Tissue Doppler Imaging Is an Independent Predictor of Mortality in the General Population
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DOI：
10.1161/circulationaha.108.793471
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发表时间：
2009-05-26
期刊：
影响因子：
37.8
通讯作者：
Jensen, Jan S.
中科院分区：
文献类型：
--
作者：
Mogelvang, Rasmus;Sogaard, Peter;Jensen, Jan S.
背景-组织多普勒成像（TDI）检测左心室功能不全的心力衰竭和正常射血分数的患者，但TDI在一般population.Methods和结果，在哥本哈根市心脏研究，一个大型的社区为基础的人口研究，心脏功能进行了评估，在1036名参与者的预后意义均为常规超声心动图和TDI。使用6个二尖瓣环部位的收缩期峰值（s '）、舒张早期（e'）和舒张晚期（a '）速度的平均值。TDI还通过舒张和收缩性能的组合指数（eas指数）进行定量：e '/（a' x s '）。在随访期间（中位数，5.3年），90名参与者死亡。TDI显示的左心室功能不全，以低s'表示（危险比，每减少1 cm/s为1.23; P
Background-Tissue Doppler imaging (TDI) detects left ventricular dysfunction in patients with heart failure and normal ejection fraction, but the prognostic significance of left ventricular dysfunction by TDI in the general population is unknown.Methods and Results-Within the Copenhagen City Heart Study, a large community-based population study, cardiac function was evaluated in 1036 participants by both conventional echocardiography and TDI. Averages of peak systolic (s'), early diastolic (e'), and late diastolic (a') velocities from 6 mitral annular sites were used. TDI was furthermore quantified by a combined index (eas index) of diastolic and systolic performance: e'/(a' x s'). During follow-up (median, 5.3 years), 90 participants died. Left ventricular dysfunction by TDI, in terms of low s' (hazard ratio, 1.23 per 1-cm/s decrease; P