Surfaces Containing Sharp Nanostructures Enhance Antibiotic Efficacy
Surfaces Containing Sharp Nanostructures Enhance Antibiotic Efficacy
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DOI：
10.1021/acs.nanolett.2c02182
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发表时间：
2022-07-28
期刊：
影响因子：
10.8
通讯作者：
Vasilev, Krasimir
中科院分区：
文献类型：
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作者：
Bright, Richard;Hayles, Andrew;Vasilev, Krasimir
随着医疗器械植入率的不断提高，植入物相关感染的负担也相应增加。为了缓解这一威胁，许多研究都指向通过各种手段进行抗菌表面改性的发展。最近的一种方法涉及含有尖锐纳米结构的表面，这些结构能够在接触时杀死细菌。在此，我们报道了金黄色葡萄球菌与这种表面纳米结构之间的机械相互作用导致病原体对糖肽抗生素万古霉素的敏化。我们证明，这是由于细胞壁受损和细菌对活性氧的防御受阻所致。这项研究的结果有望在临床上产生效果，因为纳米结构抗菌表面与医院常用抗生素的结合可能会改进抗菌治疗策略，帮助临床医生使用更低的抗生素浓度来预防和治疗种植相关感染，而不是依赖往往效果不佳的侵入性翻修手术。
The ever-increasing rate of medical device implantations is met by a proportionately high burden of implant-associated infections. To mitigate this threat, much research has been directed toward the development of antibacterial surface modifications by various means. One recent approach involves surfaces containing sharp nanostructures capable of killing bacteria upon contact. Herein, we report that the mechanical interaction between Staphylococcus aureus and such surface nanostructures leads to a sensitization of the pathogen to the glycopeptide antibiotic vancomycin. We demonstrate that this is due to cell wall damage and impeded bacterial defenses against reactive oxygen species. The results of this study promise to be impactful in the clinic, as a combination of nanostructured antibacterial surfaces and antibiotics commonly used in hospitals may improve antimicrobial therapy strategies, helping clinicians to prevent and treat implant-associated infections using reduced antibiotic concentrations instead of relying on invasive revision surgeries with often poor outcomes.