Regioselective Ring-Opening Nucleophilic Addition of Aziridines through Photoredox Catalyst
Regioselective Ring-Opening Nucleophilic Addition of Aziridines through Photoredox Catalyst
复制标题
通过光氧化还原催化剂进行氮丙啶的区域选择性开环亲核加成
DOI：
10.1002/adsc.201400476
复制
发表时间：
2014-09-15
影响因子：
5.4
通讯作者：
Xia, Wujiong
中科院分区：
文献类型：
--
作者：
Sun, Hongnan;Yang, Chao;Xia, Wujiong
建立了一种温和而高效的方法，通过可见光氧化还原催化进行区域选择性开环亲核加成反应，为1,2-双功能化合物的合成提供了一种实用的途径。此外，在温和的条件下，手性氮吡啶也可以实现非外消旋氨基醚的区域选择性合成。最后，提出了一种可能的反应机理，并通过对照实验进行了进一步验证。
A mild and efficient procedure was developed for the regioselective ring-opening nucleophilic addition reactions of aziridines via visible light photoredox catalysis, that provides a practical synthetic access to 1,2-bifunctional compounds. Furthermore, the regioselective synthesis of non-racemic amino ethers from chiral aziridine could also be achieved under mild conditions. Finally, a possible reaction mechanism was proposed and further supported by control experiments.