Abnormal expression of E-cadherin in tumor cells is associated with poor prognosis of gastric carcinoma
Abnormal expression of E-cadherin in tumor cells is associated with poor prognosis of gastric carcinoma
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DOI：
10.1002/jso.23008
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发表时间：
2012-09-01
影响因子：
2.5
通讯作者：
Zan, Wen-Hua
中科院分区：
文献类型：
--
作者：
Li, Yin;Chen, Chuang-Qi;Zan, Wen-Hua
背景与目的探讨肝细胞生长因子（HGF）、c-Met和E-cadherin在胃癌中的表达及其与临床病理参数和预后的关系。方法收集114例胃癌组织标本，采用免疫组织化学方法检测组织芯片中HGF、c-Met和E-cadherin的表达。对免疫组化染色结果与临床病理参数及随访资料进行相关性分析。结果60.5%（69/114）的乳腺癌组织中E-cadherin表达异常，且E-cadherin的表达与肿瘤的深度有关（P = 0.001）。0.003），淋巴结转移（P = 0.001）。0.001）和晚期临床分期（P <0.01）。0.001）。HGF和c-Met的高表达率分别为64.0%（73/114）和82.4%（94/114）。c-Met的高表达与临床分期密切相关（P <0.05）。0.001）和淋巴结转移（P <0.01）。0.011）的GC。单因素生存分析显示，HGF、c-Met高表达及E-cadherin异常与胃癌患者预后不良相关。而E-cadherin的异常表达（P <0.05）与E-cadherin的表达（P <0.05）无显著性差异。0.001）和肿瘤深度（P = 0.001）。0.010）是胃癌患者总生存率的独立预后因素。结论胃癌组织中HGF/c-Met、E-cadherin的表达与胃癌患者的预后密切相关。E-cadherin异常表达可作为胃癌患者预后的独立预测因素。外科肿瘤学杂志2012; 106：304-310. (c)2012 Wiley Periodicals，Inc.
Background and Objectives The purpose of this study was to clarify the relationship of hepatocyte growth factor (HGF), c-Met, and E-cadherin with clinicopathological parameters and prognosis in gastric carcinoma (GC). Methods 114 specimens were collected from GC patients and expression of HGF, c-Met, and E-cadherin in tissue microarray was evaluated by immunohistochemical staining. Correlation between immunostainings and clinicopathological parameters, follow-up data of patients, was analyzed statistically. Results Abnormal E-cadherin expression was found in 60.5% (69/114) and associated with tumor depth (P?=?0.003), lymph node metastasis (P?=?0.001) and advanced clinical stage (P?=?0.001). High-expression of HGF and c-Met were found in 64.0% (73/114) and 82.4% (94/114), respectively. High c-Met expression was significantly associated with advanced clinical stage (P?=?0.001) and lymph node metastasis (P?=?0.011) of GC. In univariate survival analysis, high-expression of HGF and c-Met, and abnormal E-cadherin were significantly associated with poor prognosis of GC patients. However, only abnormal E-cadherin expression (P?=?0.001) and tumor depth (P?=?0.010) emerged as strong independent prognostic factors for overall survival of GC patients. Conclusion We found significant correlation among HGF/c-Met, E-cadherin expression and worse prognosis of patients with GC. Abnormal E-cadherin expression may serve as an independent predictive factor for prognosis of GC patients. J. Surg. Oncol. 2012; 106:304-310. (c) 2012 Wiley Periodicals, Inc.