Role of natural killer cells in resistance to systemic cryptococcosis.
Role of natural killer cells in resistance to systemic cryptococcosis.
复制标题
自然杀伤细胞在抵抗系统性隐球菌病中的作用。
DOI：
10.1002/jlb.50.2.151
复制
发表时间：
1991
影响因子：
5.5
通讯作者：
Balish,E
中科院分区：
文献类型：
--
作者：
Salkowski,CA;Balish,E
These studies demonstrate thatCryptococccus neoformansinfection induced a dose-dependent augmentation of splenic natural killer (NK) cell activity by bg/+, but not bg/bg mice. To directly assess the role of NK cells in resistance toC. neoformans, bg/+ and bg/bg mice were treated with anti-NK-1.1 monoclonal antibody (mAb). Anti-NK-1.1-treatment abrogated the augmented NK cell activity observed during C.neoformansinfection in bg/+ mice. Anti-NK-1.1-treated bg/+ mice had higherC. neoformanscolony forming units (CFU) in their lungs on days 3 and 7 after intravenous (i.v.) challenge than control bg/+ mice. Moreover, the number ofC. neoformansCFU in the lungs of anti-NK-1.1-treated bg/+ mice on days 3 and 7 were similar to those observed for infected bg/bg mice. By day 14, however, no differences inC. neoformansCFU were evident in the lungs of anti-NK-1.1-treated and control bg/+ mice. Anti-NK-1.1-treatment did not alter either the growth ofC. neoformansin the spleens, livers, kidneys, or brain of bg/+ mice or the susceptibility of bg/bg mice to systemic cryptococcosis. These studies suggest that NK cells do not play a role in resistance to systemic cryptococcosis in the spleen, but do appear to play an early, but transient role in resistance toC. neoformansin the lungs. Overall, congenital defects in polymorphonuclear neutrophils (PMNs) and macrophages (Mφs), in addition to defects in NK cells, contribute to the enhanced susceptibility of bg/bg mice to systemic cryptococcosis.
