Why detailed model gene studies in higher eukaryotes are still necessary.
Why detailed model gene studies in higher eukaryotes are still necessary.
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为什么高等真核生物中的详细模型基因研究仍然是必要的。
作者：
Bonifer C
基因表达程序的改变由序列特异性DNA结合蛋白控制，这些蛋白与表观遗传调控机制相互作用。这些过程的总和包括一个基因调控网络和分化过程涉及这些网络之间的转换。然而，虽然在识别网络组件方面取得了很大进展，但这个列表并不完整，我们仍然不完全了解它们如何协同工作。在这篇文章中，我认为这种知识缺乏的一个原因是，我们仍然不了解是什么控制着细胞阶段和细胞状态特异性调控单个基因，并回顾了突出这一概念的例子。
Alterations in gene expression programmes are controlled by sequence‐specific DNA‐binding proteins that interact with the epigenetic regulatory machinery. The sum of such processes comprises a gene regulatory network and differentiation processes involve transitions between such networks. However, while great progress has been made to identify network components, this list is not complete, and we still do not fully understand how they work together. In this article, I argue that one reason for this lack of knowledge is the fact that we still do not understand what controls the cell stage and cell state‐specific regulation of individual genes and review examples highlighting this notion.