Bone mineral in pre- and postmenopausal women with insulin-depdendent and non-insulin-dependent diabetes mellitus
Bone mineral in pre- and postmenopausal women with insulin-depdendent and non-insulin-dependent diabetes mellitus
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DOI：
10.1007/s001980050232
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发表时间：
1999-01-01
影响因子：
4
通讯作者：
Svendsen, OL
中科院分区：
文献类型：
--
作者：
Christensen, JO;Svendsen, OL
该研究的目的是比较患有胰岛素依赖型糖尿病（IDDM）、非胰岛素依赖型糖尿病（NIDDM）的绝经前和绝经后女性与正常参考女性的骨矿物质密度（BMD）和骨转换。在一项横断面研究中，从门诊分别招募了 31 名和 II 级绝经前 IDDM 和 NIDDM 患者以及 22 名和 21 名绝经后 IDDM 和 NIDDM 患者。测量前臂、脊柱、股骨和全身的 BMD 以及骨转换的生化标志物，并与正常健康绝经前和绝经后妇女测量得到的参考值进行比较。绝经后（而非绝经前）IDDM 患者的 BMD 值低于 NIDDM 患者。绝经后NIDDM患者的BMD值高于正常女性。 IDDM 和 NIDDM 患者之间 BMD 的差异可以通过 NIDDM（肥胖）和 IDDM（瘦）女性之间的体重差异进行统计解释。 IDDM 和 NIDDM 患者绝经后的骨转换标志物均显着高于绝经前。与绝经后IDDM患者和参考值相比，绝经后NIDDM患者的骨钙素显着降低。除此之外，NIDDM 和 IDDM 患者之间的骨转换标志物没有差异。总之，绝经后 IDDM 患者的 BMD 相对降低，而 NIDDM 患者似乎相对免受绝经后骨质流失的影响。
The aim of the study was to compare bone mineral density (BMD) and bone turnover in pre- and postmenopausal women with insulin-dependent diabetes mellitus (IDDM), non-insulin-dependent diabetes mellitus (NIDDM) and normal reference women. In a cross-sectional study 31 and II premenopausal and 22 and 21 postmenopausal IDDM and NIDDM patients, respectively, were recruited from an outpatient clinic. BMD in the forearm, spine, femur and total body and biochemical markers of bone turnover were measured and compared with reference values obtained from measurements of normal healthy pre- and postmenopausal women. Postmenopausally, but not premenopausally, IDDM patients had lower BMD values than NIDDM patients. Postmenopausal NIDDM patients had higher BMD value than normal women. The differences in BMD between IDDM and NIDDM patients could be explained statistically by differences in body weight between the NIDMM (obese) and IDDM (lean) women. Markers of bone turnover were significantly higher postmenopausally than premenopausally in both IDDM and NIDDM patients. Osteocalcin was significantly lower in postmenopausal NIDDM compared with postmenopausal IDDM patients and reference values. Otherwise there were no differences in the markers of bone turnover between NIDDM and IDDM patients. In conclusion, postmenopausal IDDM patients have a relatively decreased BMD, whereas NIDDM patients seem to be relatively protected from postmenopausal bone loss.