ISOLATION OF A T-LYMPHOTROPIC VIRUS FROM DOMESTIC CATS WITH AN IMMUNODEFICIENCY-LIKE SYNDROME
ISOLATION OF A T-LYMPHOTROPIC VIRUS FROM DOMESTIC CATS WITH AN IMMUNODEFICIENCY-LIKE SYNDROME
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DOI：
10.1126/science.3643650
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发表时间：
1987-02-13
期刊：
影响因子：
56.9
通讯作者：
YAMAMOTO, JK
中科院分区：
文献类型：
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作者：
PEDERSEN, NC;HO, EW;YAMAMOTO, JK
从一个猫舍的猫中分离出一种高度亲T淋巴细胞的病毒，该猫舍中所有动物的猫白血病病毒血清学检测均为阴性。一个猫栏中的许多猫已经死亡，还有几只出现了类似免疫缺陷的综合征。猫舍中18只正常猫只有1只显示出感染这种新病毒的血清学证据，而25只有健康不良迹象的猫中有10只对该病毒血清学呈阳性。这种新的猫逆转录病毒暂时被命名为猫亲T淋巴细胞慢病毒，它在抗原性上似乎与人免疫缺陷病毒不同。没有证据表明该病原体从猫传播给人。通过来自自然感染动物的血液或血浆进行实验性感染的小猫在几周后出现全身性淋巴结病，短暂发热和白细胞减少，并且在感染5个月后仍持续表现出全身性淋巴结病。
A higly T-lymphotropic virus was isolated from cats in a cattery in which all the animals were seronegative for feline leukemia virus. A number of cats in one pen had died and several had an immunodeficiency-like syndrome. Only 1 of 18 normal cats in the cattery showed serologic evidence of infection with this new virus, where 10 of 25 cats with signs of ill health were seropositive for the virus. Tentatively designated feline T-lymphotropic lentivirus, this new feline retrovirus appears to be antigenically distinct from human immunodeficiency virus. There is no evidence for cat-to-human transmission of the agent. Kittens experimentally infected by way of blood or plasma from naturally infected animals developed generalized lymphadenopathy several weeks later, became transiently febrile and leukopenic, and continued to show a generalized lymphadenopathy 5 months after infection.