Design, synthesis, and evaluation of phenylglycinols and phenyl amines as agonists of GPR88
Design, synthesis, and evaluation of phenylglycinols and phenyl amines as agonists of GPR88
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DOI：
10.1016/j.bmcl.2015.01.036
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发表时间：
2015-04-01
影响因子：
2.7
通讯作者：
Macor, John E.
中科院分区：
文献类型：
--
作者：
Dzierba, Carolyn D.;Bi, Yingzhi;Macor, John E.
GPR88活性的小分子调节剂（激动剂、拮抗剂或调节剂）作为治疗包括精神分裂症在内的多种精神疾病的潜在药物而受到关注。制备了一系列苯基甘二醇和苯胺类似物，并对其GPR88激动剂活性和药代动力学（PK）特性进行了评价。(C) 2015 Elsevier Ltd.版权所有。
Small molecule modulators of GPR88 activity (agonists, antagonists, or modulators) are of interest as potential agents for the treatment of a variety of psychiatric disorders including schizophrenia. A series of phenylglycinol and phenylamine analogs have been prepared and evaluated for their GPR88 agonist activity and pharmacokinetic (PK) properties. (C) 2015 Elsevier Ltd. All rights reserved.