Monoclonal antibodies: versatile platforms for cancer immunotherapy.
Monoclonal antibodies: versatile platforms for cancer immunotherapy.
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DOI:
10.1038/nri2744
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发表时间:
2010-05
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Antibodies have emerged as important therapeutics for cancer. Recently, it has become clear that antibodies possess multiple clinically relevant mechanisms of action. Many clinically useful antibodies can manipulate tumour-related signalling. In addition, antibodies exhibit various immunomodulatory properties and, by directly activating or inhibiting molecules of the immune system, antibodies can promote the induction of anti-tumour immune responses. These immunomodulatory properties can form the basis for new cancer treatment strategies.
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