Deciphering the complexities of atopic dermatitis: shifting paradigms in treatment approaches.
Deciphering the complexities of atopic dermatitis: shifting paradigms in treatment approaches.
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DOI：
10.1016/j.jaci.2014.08.008
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发表时间：
2014-10
影响因子：
14.2
通讯作者：
Guttman-Yassky, Emma
中科院分区：
文献类型：
--
作者：
Leung, Donald Y. M.;Guttman-Yassky, Emma
特应性皮炎（AD）是最常见的慢性炎症性皮肤病。它通常先于食物过敏和哮喘的发展。最近对AD的见解揭示了表皮上皮终末分化异常，导致角质层缺陷，从而增强过敏原渗透和全身性IgE致敏。特应性皮肤也易于被病原微生物定植或感染，最显著的是金黄色葡萄球菌和单纯疱疹病毒（HSV）。这种异常皮肤屏障的原因是复杂的，由遗传，环境和免疫因素的组合驱动。这些因素可能解释了这种皮肤病的AD发作、严重程度和自然史的异质性。最近的研究表明，AD的预防可以通过保护皮肤屏障的早期干预来实现。病变性AD的发作需要有效控制局部和全身免疫激活以进行最佳管理。早期干预可以改善AD的长期结局，并减少导致胃肠道和呼吸道相关过敏性疾病的全身过敏原致敏作用。
Atopic dermatitis (AD) is the most common chronic inflammatory skin disease. It often precedes the development of food allergy and asthma. Recent insights into AD reveal abnormalities in terminal differentiation of the epidermal epithelium leading to a defective stratum corneum, which allows enhanced allergen penetration and systemic IgE sensitization. Atopic skin is also predisposed to colonization or infection by pathogenic microbes, most notably Staphylococcus aureus and herpes simplex virus (HSV). Causes of this abnormal skin barrier are complex and driven by a combination of genetic, environmental and immunologic factors. These factors likely account for the heterogeneity of AD onset, severity and natural history of this skin disease. Recent studies suggest prevention of AD can be achieved by early interventions protecting the skin barrier. Onset of lesional AD requires effective control of local and systemic immune activation for optimal management. Early intervention may improve long term outcomes for AD and reduce the systemic allergen sensitization leading to associated allergic diseases in the gastrointestinal and respiratory tract.
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影响因子：
14.2
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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