New insights into pathogen-mediated modulation of host RNA splicing.
New insights into pathogen-mediated modulation of host RNA splicing.
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DOI：
10.1007/s44154-022-00053-2
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发表时间：
2022-08-15
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前体mRNA的选择性剪接（alternative splicing，AS）调控已被证明是植物免疫系统的基本层次之一。病原体如何通过分泌的效应物扰乱植物AS过程以抑制植物免疫力仍然知之甚少。在最近的研究中，Gui等人揭示了先前鉴定的疫霉属效应子PSR 1干扰宿主RNA剪接机制以调节小RNA生物合成，导致植物免疫力受损。该研究为AS过程在病原体-宿主相互作用中的重要性提供了新的见解。
Alternative splicing (AS) regulation of pre-mRNA has been proven to be one of the fundamental layers of plant immune system. How pathogens disrupt plant AS process to suppress plant immunity by secreted effectors remain poorly understood. In the recent study, Gui et al. revealed that a previously identified effector PSR1 of Phytophthora interferes with host RNA splicing machinery to modulate small RNA biogenesis, leading to compromised plant immunity. The study provided a novel insight into the importance of AS process during pathogen-host interactions.