Increased Frequency of Prediabetes in Patients With Irritable Bowel Syndrome
Increased Frequency of Prediabetes in Patients With Irritable Bowel Syndrome
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DOI：
10.1097/maj.0b013e31819f7587
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发表时间：
2009-08-01
影响因子：
3.1
通讯作者：
Alcelik, Aytekin
中科院分区：
文献类型：
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作者：
Gulcan, Erim;Taser, Figen;Alcelik, Aytekin
本研究的目的是比较肠易激综合征（IBS）病例和匹配对照组中前驱糖尿病（空腹血糖受损和/或糖耐量受损被认为是2型糖尿病（DM）的前兆）的发生率。92例IBS患者和104例健康对照者被纳入本研究。2型糖尿病被认为是两组的排除标准。检查空腹血糖、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇和甘油三酯水平;禁食1晚后，给予75 g葡萄糖口服葡萄糖耐量试验，并检查2小时后的血糖水平。虽然甘油三酯水平没有显著差异，但总胆固醇、高密度脂蛋白胆固醇和低密度脂蛋白胆固醇水平存在显著差异（分别为P <0.001、0.001和< 0.001）。与对照组相比，IBS组的这些指标升高。糖尿病前期（被认为是2型糖尿病的第一阶段）的发生率在IBS组中也显著较高（P < 0.001）。在协方差模型分析中调整了潜在的混杂因素（如年龄、血脂水平和人体测量指标）后，IBS组的前驱糖尿病发生率显著高于对照组（P < 0.001）。因此，鉴于IBS中糖尿病前期的发生率较高，IBS可能间接表明糖尿病的风险较高。进一步的调查将是必要的，以充分阐明这些意见背后的机制。
The aim of this study was to compare the occurrence of prediabetes [impaired fasting glucose and/or impaired glucose tolerance are considered to be precursors to type 2 diabetes mellitus (DM)) in irritable bowel syndrome (IBS) cases and matched controls. Ninety-two patients with IBS and 104 healthy matched controls were included in this study. Type 2 DM was considered an exclusion criterion in both groups. Fasting blood glucose, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglyceride levels were examined; after I night of fasting, an oral glucose tolerance test with 75 g glucose was administered, and the blood glucose levels after 2 hours were examined. Although there were no significant differences in the triglyceride levels, significant differences were found for total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol levels (P < 0,001, 0.001, and < 0.001, respectively). These measures were found to be elevated in the IBS group compared with the control group. The frequency of prediabetes, which is regarded as the first stage of type 2 DM, was also found to be significantly higher in the IBS group (P < 0.001). After adjusting for potential confounders, such as age, lipid levels, and anthropometric measures in the analysis of covariance models, prediabetes was significantly more frequent in the IBS group than in the control group (P < 0.001). Thus, given the higher prediabetes occurrence in IBS, IBS may indirectly indicate a higher risk of DM. Further investigations will be necessary to fully elucidate the mechanisms behind these observations.