Image-guided thermal ablation of tumors increases the plasma level of interleukin-6 and interleukin-10.
Image-guided thermal ablation of tumors increases the plasma level of interleukin-6 and interleukin-10.
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DOI：
10.1016/j.jvir.2013.02.015
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发表时间：
2013-08
期刊：
影响因子：
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通讯作者：
Solomon SB
中科院分区：
文献类型：
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作者：
Erinjeri JP;Thomas CT;Samoilia A;Fleisher M;Gonen M;Sofocleous CT;Thornton RH;Siegelbaum RH;Covey AM;Brody LA;Alago W Jr;Maybody M;Brown KT;Getrajdman GI;Solomon SB
目的：确定在图像引导下热消融治疗人类肿瘤后血浆细胞因子水平的变化，并确定独立预测血浆细胞因子水平变化的因素。36例患者分别于消融前、消融后(48h内)和随访(消融后1~5周)3个时间点采集全血标本。采用多重免疫分析法检测血浆IL-1α、IL-2、IL-6、IL-10和肿瘤坏死因子α(TNFa)水平。以细胞因子水平为因变量，样本收集、时间、年龄、性别、原发诊断、转移状态、消融部位、消融类型为自变量进行单因素和多因素分析。消融后血浆IL-6水平较消融前显著升高(9.6+/−31倍，p<；0.002)。IL-10在消融后显著升高(1.90+/−，2.8倍，p<；0.02)。消融后血浆IL-1a、IL-2和TNFa水平无明显变化。冷冻消融组IL-6水平变化最大(54倍)，射频消融组和微波消融组分别为3.6和3.4倍。黑色素瘤消融后48小时IL-6变化最大(92倍)，其次是肾癌(26倍)、肝癌(8倍)和肺癌(6倍)。多变量分析显示消融类型(P<；0.0003)和原始诊断(P<；0.03)是消融后IL-6变化的独立预测因子。年龄是消融后IL-10水平的唯一独立预测因子(p<；0.019)。图像引导下肿瘤热消融可提高血浆IL-6和IL-10水平，但不增加IL-1a、IL-2或TNFa水平。
To identify changes in plasma cytokine levels following image-guided thermal ablation of human tumors and to identify the factors that independently predict changes in plasma cytokine levels. Whole blood samples were collected from 36 patients at 3 time points: pre-ablation, post-ablation (within 48 hours), and in follow-up (1–5 weeks after ablation). Plasma levels of IL-1a, IL-2, IL-6, IL-10 and TNFa were measured using a multiplex immunoassay. Univariate and multivariate analyses were performed using cytokine level as the dependent variable and sample collection, time, age, sex, primary diagnosis, metastatic status, ablation site, and ablation type as the independent variables. There was a significant increase in the plasma level of IL-6 post-ablation when compared to pre-ablation (9.6+/−31 fold, p<0.002). IL-10 also showed a significant increase postablation (1.9 +/−2.8 fold, p<0.02). Plasma levels of IL-1a, IL-2, and TNFa were not significantly changed after ablation. Cryoablation resulted in the largest change in IL-6 level (>54 fold), while radiofrequency and microwave ablation showed 3.6 and 3.4-fold changes, respectively. Ablation of melanomas showed the largest change in IL-6 48 hours after ablation (92×), followed by ablation of kidney (26×), liver (8×), and lung (6×) cancers. Multivariate analysis revealed that ablation type (p<0.0003), and primary diagnosis (p<0.03) were independent predictors of changes to IL-6 following ablation. Age was the only independent predictor of IL-10 levels following ablation (p<0.019). Image guided thermal ablation of tumors increases the plasma level of IL-6 and IL-10, without increasing the plasma level of IL-1a, IL-2, or TNFa.