Ortholog genes from cactophilic Drosophila provide insight into human adaptation to hallucinogenic cacti.
Ortholog genes from cactophilic Drosophila provide insight into human adaptation to hallucinogenic cacti.
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DOI：
10.1038/s41598-022-17118-x
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发表时间：
2022-08-01
影响因子：
4.6
通讯作者：
Soto, Ignacio M.
中科院分区：
文献类型：
--
作者：
Padro, Julian;De Panis, Diego N.;Luisi, Pierre;Dopazo, Hernan;Szajnman, Sergio;Hasson, Esteban;Soto, Ignacio M.
生活方式和饮食习惯的文化转变一直是人类进化的关键驱动力。然而，虽然基因组适应的大多数证据与狩猎采集过渡到农业社会有关，但对其他主要文化表现的影响知之甚少。萨满教被认为是最古老的宗教，在人类史前史的大部分时间里占主导地位，至今仍在许多土著居民中盛行。来自民族考古学研究的几条证据证明了精神植物在南美文化中的连续性和重要性。然而，尽管次级代谢产物在人类健康中的重要性众所周知，但对其在种族差异演变中的作用知之甚少。在这里，我们确定了候选基因的适应致幻仙人掌在安第斯土著人口具有悠久的萨满习俗的历史。我们使用嗜仙人掌苍蝇果蝇的全基因组表达数据，将其暴露于致幻柱状仙人掌（也被人类食用），以识别表现出生物碱耐受性适应性足迹的直系同源基因。人类基因组分析显示，在中部安第斯山脉的土著人群中，最近的正选择下进化出一套直系同源基因。我们的研究结果提供了在艾马拉人和盖丘亚人种群中与生物碱毒性、异生物质代谢和神经元可塑性相关的遗传变异中进行选择的证据，这表明宗教习俗驱动的基因文化协同进化可能是一个过程。
Cultural transformations of lifestyles and dietary practices have been key drivers of human evolution. However, while most of the evidence of genomic adaptations is related to the hunter-gatherer transition to agricultural societies, little is known on the influence of other major cultural manifestations. Shamanism is considered the oldest religion that predominated throughout most of human prehistory and still prevails in many indigenous populations. Several lines of evidence from ethno-archeological studies have demonstrated the continuity and importance of psychoactive plants in South American cultures. However, despite the well-known importance of secondary metabolites in human health, little is known about its role in the evolution of ethnic differences. Herein, we identified candidate genes of adaptation to hallucinogenic cactus in Native Andean populations with a long history of shamanic practices. We used genome-wide expression data from the cactophilic fly Drosophila buzzatii exposed to a hallucinogenic columnar cactus, also consumed by humans, to identify ortholog genes exhibiting adaptive footprints of alkaloid tolerance. Genomic analyses in human populations revealed a suite of ortholog genes evolving under recent positive selection in indigenous populations of the Central Andes. Our results provide evidence of selection in genetic variants related to alkaloids toxicity, xenobiotic metabolism, and neuronal plasticity in Aymara and Quechua populations, suggesting a possible process of gene-culture coevolution driven by religious practices.
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影响因子：
3.4
作者：
Dobon, Begona;Rossell, Carla;Bertranpetit, Jaume
通讯作者：
Bertranpetit, Jaume
影响因子：
7
作者：
Baker BM;Mokashi SS;Shankar V;Hatfield JS;Hannah RC;Mackay TFC;Anholt RRH
通讯作者：
Anholt RRH
影响因子：
2.6
作者：
DERIOS, MD
通讯作者：
DERIOS, MD
影响因子：
56.9
作者：
GEBER, WF
通讯作者：
GEBER, WF
影响因子：
9.8
作者：
Bhatia, Gaurav;Patterson, Nick;Price, Alkes L.
通讯作者：
Price, Alkes L.