Circadian clocks and vascular function.
Circadian clocks and vascular function.
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DOI：
10.1161/circresaha.109.211706
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发表时间：
2010-03-19
影响因子：
20.1
通讯作者：
FitzGerald GA
中科院分区：
文献类型：
--
作者：
Paschos GK;FitzGerald GA
生物钟调节生理学的许多方面，包括心血管功能。血管内皮细胞、平滑肌细胞和成纤维细胞中存在内部振荡器。血管张力和血栓形成——心血管不良事件相关的血管功能的两个关键要素——呈现出昼夜节律性。在这篇综述中，我们描述了因生物钟离散元件的基因破坏而导致的血管功能变化。
The circadian clock regulates many aspects of physiology including cardiovascular function. Internal oscillators exist in endothelial, smooth muscle cells and fibroblasts of the vasculature. Vascular tone and thrombus formation – two key elements of vascular function in regard to adverse cardiovascular events - exhibit diurnal rhythmicity. In this review, we describe changes in vascular function that result from genetic disruption of discrete elements of the circadian clock.