A novel method for local administration of strontium from implant surfaces
A novel method for local administration of strontium from implant surfaces
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DOI：
10.1007/s10856-010-4022-8
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发表时间：
2010-05-01
影响因子：
3.7
通讯作者：
Engqvist, Hakan
中科院分区：
文献类型：
--
作者：
Forsgren, Johan;Engqvist, Hakan
本研究证明，当暴露于醋酸锶溶液时，在钛酸钠的生物活性表面上可以成功地形成一层锶矿（SrCO3）膜。这种锶酸盐薄膜被认为能够使种植体表面的锶离子局部释放，从而刺激体内骨的形成。根据不同的方法，不同类型的薄膜具有不同的锶离子释放速率，结果表明有可能调整从表面释放的锶的速率和数量。早些时候，锶被证明高度参与新骨的形成，因为它刺激成骨细胞的复制，降低破骨细胞的活性。例如，研究证明了锶的益处，在接受治疗剂量锶的患者中，骨质疏松症患者椎体压缩性骨折的数量大大减少。因此，本文建议，如果在种植体部位局部施用锶，种植体周围的骨愈合过程可能会得到改善。本文所描述的薄膜是通过简单的浸泡工艺生产的，其中碱处理的钛暴露于含有醋酸锶的水溶液中。通过在不同时间加热样品，样品暴露于模拟体液时，锶离子的释放速度不同。当暴露在模拟体液中时，含有锶的薄膜也促进了骨样磷灰石的沉淀。
This study proves that a film of Strontianite (SrCO3) successfully can be formed on a bioactive surface of sodium titanate when exposed to a strontium acetate solution. This Strontianite film is believed to enable local release of strontium ions from implant surfaces and thus stimulate bone formation in vivo. Depending on the method, different types of films were achieved with different release rates of strontium ions, and the results points at the possibility to tailor the rate and amount of strontium that is to be released from the surface. Strontium has earlier been shown to be highly involved in the formation of new bone as it stimulates the replication of osteoblasts and decreases the activity of osteoclasts. The benefit of strontium has for example been proved in studies where the number of vertebral compression fractures in osteoporotic persons was drastically reduced in patients receiving therapeutical doses of strontium. Therefore, it is here suggested that the bone healing process around an implant may be improved if strontium is administered locally at the site of the implant. The films described in this paper were produced by a simple immersion process where alkali treated titanium was exposed to an aqueous solution containing strontium acetate. By heating the samples at different times during the process, different release rates of strontium ions were achieved when the samples were exposed to simulated body fluid. The strontium containing films also promoted precipitation of bone like apatite when exposed to a simulated body fluid.