Short-term memory binding is impaired in AD but not in non-AD dementias
Short-term memory binding is impaired in AD but not in non-AD dementias
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DOI：
10.1016/j.neuropsychologia.2012.01.018
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发表时间：
2012-04-01
期刊：
影响因子：
2.6
通讯作者：
Abrahams, Sharon
中科院分区：
文献类型：
--
作者：
Della Sala, Sergio;Parra, Mario A.;Abrahams, Sharon
绑定是一种认知功能，负责整合复杂刺激内的特征（例如，形状-颜色连接）或复杂记忆内的事件（例如，名称关联）。这种功能在短期记忆（STM）和长期记忆（LTM）中都起作用，并且受到阿尔茨海默病（AD）的严重影响。然而，在STM中形成连接是唯一不受健康衰老或慢性抑郁影响的结合功能。这种特异性是否适用于其他非AD痴呆症尚不清楚。本研究调查了STM结合在AD患者和其他非AD痴呆患者的样本中使用的任务，已被证明是敏感的AD的影响。STM任务评估的是对物体、颜色以及物体和颜色的结合的自由回忆。AD、额颞叶痴呆、血管性痴呆、路易体痴呆和帕金森病相关痴呆患者在标准神经心理学评估中表现出记忆、视觉空间、执行和注意力缺陷。然而，只有AD患者表现出STM结合缺陷。即使在患者组之间对单个特征的记忆处于相似水平时，也观察到这种缺陷。回归和判别分析证实，STM结合任务占AD和非AD组之间方差的最大比例，并且具有识别AD患者的最大分类能力。STM连接绑定对执行功能的要求很小，似乎是由AD针对的记忆网络的组件，但不是由非AD痴呆。(C)2012爱思唯尔有限公司保留所有权利。
Binding is a cognitive function responsible for integrating features within complex stimuli (e.g., shape-colour conjunctions) or events within complex memories (e.g., face-name associations). This function operates both in short-term memory (STM) and in long-term memory (LTM) and is severely affected by Alzheimer's disease (AD). However, forming conjunctions in STM is the only binding function which is not affected by healthy ageing or chronic depression. Whether this specificity holds true across other non-AD dementias is as yet unknown. The present study investigated STM conjunctive binding in a sample of AD patients and patients with other non-AD dementias using a task which has proved sensitive to the effects of AD. The STM task assesses the free recall of objects, colours, and the bindings of objects and colours. Patients with AD, frontotemporal dementia, vascular dementia, lewy body dementia and dementia associated with Parkinson's disease showed memory, visuo-spatial, executive and attentional deficits on standard neuropsychological assessment. However, only AD patients showed STM binding deficits. This deficit was observed even when memory for single features was at a similar level across patient groups. Regression and discriminant analyses confirmed that the STM binding task accounted for the largest proportion of variance between AD and non-AD groups and held the greatest classification power to identify patients with AD. STM conjunctive binding places little demands on executive functions and appears to be subserved by components of the memory network which are targeted by AD, but not by non-AD dementias. (C) 2012 Elsevier Ltd. All rights reserved.