A ketogenic drink improves brain energy and some measures of cognition in mild cognitive impairment
A ketogenic drink improves brain energy and some measures of cognition in mild cognitive impairment
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DOI：
10.1016/j.jalz.2018.12.017
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发表时间：
2019-05-01
影响因子：
14
通讯作者：
Cunnane, Stephen C.
中科院分区：
文献类型：
--
作者：
Fortier, Melanie;Castellano, Christian-Alexandre;Cunnane, Stephen C.
简介：与葡萄糖不同，轻度认知障碍（MCI）患者对大脑主要替代燃料酮的摄取保持正常。生酮中链甘油三酯（kMCT）可通过为大脑提供更多的furnishing.Methods：52例MCI受试者被随机盲法分为30 g/d kMCT组和安慰剂组。在基线和6个月后评估脑酮和葡萄糖代谢（通过正电子发射断层扫描定量;主要结果）和认知能力（次要结果）。结果：接受kMCT的受试者脑酮代谢增加了230%（P <0.001），而脑葡萄糖摄取保持不变。与基线相比，kMCT的情景记忆、语言、执行功能和处理速度指标均有所改善。脑酮摄取增加与几项认知指标呈正相关。75%的参与者完成了干预。讨论：每天服用30 g kMCT，持续6个月，可以绕过大脑葡萄糖缺乏的重要部分，并改善MCI患者的几种认知结果。(C)2019年，阿尔茨海默氏症协会。爱思唯尔公司出版All rights reserved.
Introduction: Unlike for glucose, uptake of the brain's main alternative fuel, ketones, remains normal in mild cognitive impairment (MCI). Ketogenic medium chain triglycerides (kMCTs) could improve cognition in MCI by providing the brain with more fuel.Methods: Fifty-two subjectswithMCI were blindly randomized to 30 g/day of kMCT or matching placebo. Brain ketone and glucose metabolism (quantified by positron emission tomography; primary outcome) and cognitive performance (secondary outcome) were assessed at baseline and 6months later.Results: Brain ketone metabolism increased by 230% for subjects on the kMCT (P < .001) whereas brain glucose uptake remained unchanged. Measures of episodic memory, language, executive function, and processing speed improved on the kMCT versus baseline. Increased brain ketone uptake was positively related to several cognitive measures. Seventy-five percent of participants completed the intervention.Discussion: A dose of 30 g/day of kMCT taken for 6 months bypasses a significant part of the brain glucose deficit and improves several cognitive outcomes in MCI. (C) 2019 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.