SPECIFIC EFFECTS OF IDAZOXAN IN A DISTRACTION TASK - EVIDENCE THAT ENDOGENOUS NOREPINEPHRINE PLAYS A ROLE IN SELECTIVE ATTENTION IN RATS
SPECIFIC EFFECTS OF IDAZOXAN IN A DISTRACTION TASK - EVIDENCE THAT ENDOGENOUS NOREPINEPHRINE PLAYS A ROLE IN SELECTIVE ATTENTION IN RATS
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DOI：
10.1037/0735-7044.109.5.903
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发表时间：
1995-10-01
影响因子：
1.9
通讯作者：
STRUPP, BJ
中科院分区：
文献类型：
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作者：
BUNSEY, MD;STRUPP, BJ
在进行警戒和分心任务测试之前，给大鼠注射α（2）-肾上腺素能拮抗剂咪唑克生（IDZ）。在警戒任务中，大鼠在试验开始后以可变的间隔对简短的视觉线索进行鼻戳。分心的任务是相似的，除了无关的气味线索（分心），在间隔之前，一些试验的光发作。IDZ注射对警戒任务的表现没有影响。然而，在分心任务中，较高的IDZ剂量（1.0 mg/kg）调制的倾向，使一个过早的反应时，分心。值得注意的是，影响的方向随着大鼠注意力分散的基线水平而变化。这种效应模式表明，内源性去甲肾上腺素（NE）影响分心和/或选择性注意。
Rats were injected with the alpha(2)-adrenergic antagonist idazoxan (IDZ) prior to testing on vigilance and distraction tasks. In the vigilance task, rats responded with nose pokes to brief visual cues presented at variable intervals following trial onset. The distraction task was similar except that irrelevant odor cues (distractors) were presented in the interval prior to light onset on some trials. IDZ injection had no effect on performance in the vigilance task. In the distraction task, however, the higher IDZ dose (1.0 mg/kg) modulated the propensity to make a premature response when the distracters were presented. Notably, the direction of the effect varied with the rats' baseline level of distractibility. This pattern of effects suggests that endogenous norepinephrine (NE) influences distractibility and/or selective attention.