DIURNAL FLUCTUATIONS IN TRIGLYCERIDE, FREE FATTY ACIDS, AND INSULIN DURING SUCROSE CONSUMPTION AND INSULIN INFUSION IN MAN
DIURNAL FLUCTUATIONS IN TRIGLYCERIDE, FREE FATTY ACIDS, AND INSULIN DURING SUCROSE CONSUMPTION AND INSULIN INFUSION IN MAN
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DOI：
10.1172/jci106528
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发表时间：
1971-01-01
影响因子：
15.9
通讯作者：
NESTEL, PJ
中科院分区：
文献类型：
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作者：
BARTER, PJ;CARROLL, KF;NESTEL, PJ
以蔗糖为唯一卡路里来源的受试者在2-3天的时间里循环甘油三酯、游离脂肪酸(FFA)、胰岛素和葡萄糖的一系列变化被测量。这些蔗糖要么在白天隔夜禁食(19名受试者)，要么在白天和晚上连续3小时进餐(7名受试者)。另外5名受试者在日间喂养方案中过夜注射胰岛素，以确定对甘油三酯浓度的影响。所有受试者的甘油三酯浓度在研究过程中都有所增加，但这种反应有明显的昼夜规律，即使在持续喂养的研究中也是如此。甘油三酯的升高主要发生在夜间，而在白天，甘油三酯浓度经常下降。当注射胰岛素时，隔夜的升幅明显较小。在白天和持续喂养方案中，FFA和胰岛素也有昼夜波动。与甘油三酯一样，血浆FFA在夜间上升，白天下降，而胰岛素在白天上升，夜间下降。对日间和夜间变化的单独统计分析表明，甘油三酯的变化与这两个时期的胰岛素变化显著但呈负相关。甘油三酯和游离脂肪酸的变化在白天呈正相关，在夜间变化不明显。数据显示，当食用蔗糖2-3天时，甘油三酯浓度普遍增加，其上叠加甘油三酯、胰岛素和游离脂肪酸浓度的主要日波动。提示甘油三酯与胰岛素变化之间的高度显著的负相关关系可能是通过胰岛素对甘油三酯的清除作用来实现的。
Serial changes in circulating triglyceride, free fatty acids (FFA), insulin, and glucose have been measured in human subjects fed sucrose as the sole source of calories for 2- or 3-day periods. The sucrose was given either during the day with overnight fasting (19 subjects) or as continual 3-hour meals during the day and night (seven subjects). Insulin was infused overnight in five additional subjects on the day-feeding regimen to determine the effect on triglyceride concentration.The concentration of triglyceride increased during the study in all subjects, but there was a clear diurnal pattern in the response which was present even in the continual feeding studies. The rise in triglyceride occurred mainly overnight, and during the day there was frequently a fall in the concentration. The overnight increase was significantly less when insulin was infused. There were also diurnal fluctuations in FFA and insulin in both daytime and continual feeding regimens. The plasma FFA, like triglyceride, rose during the night and fell during the day while the insulin rose during the day and fell overnight.Separate statistical analysis of the daytime and overnight changes revealed that the changes in triglyceride were significantly but negatively correlated with changes in insulin during both periods. The changes in triglyceride and FFA were positively correlated during the day but not significantly related during the night. The data show that when sucrose is eaten for 2 or 3 days, there is a general increase in triglyceride concentration upon which are superimposed major diurnal fluctuations in the concentrations of triglyceride, insulin, and FFA. It is suggested that the highly significant inverse relationship between changes in triglyceride and insulin may be mediated through an effect of insulin on triglyceride removal.