Mitigation of Fumonisin Biomarkers by Green Tea Polyphenols in a High-Risk Population of Hepatocellular Carcinoma.
Mitigation of Fumonisin Biomarkers by Green Tea Polyphenols in a High-Risk Population of Hepatocellular Carcinoma.
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DOI：
10.1038/srep17545
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发表时间：
2015-12-02
影响因子：
4.6
通讯作者：
Wang JS
中科院分区：
文献类型：
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作者：
Xue KS;Tang L;Cai Q;Shen Y;Su J;Wang JS
绿茶多酚（GTP）对多种致癌物诱导的致瘤作用具有很强的抑制作用。在这项研究中，我们评估了从干预试验中收集的血液和尿液样本中，GTP对伏马菌素B1（一种2B类致癌物）生物标志物的缓解作用。共招募124名暴露者，随机分配低剂量组（GTP 500 mg, n = 42）、高剂量组（GTP 1000 mg, n = 41）或安慰剂组（n = 41），为期3个月。干预1个月后，与安慰剂组相比，高剂量组尿FB1显著降低（p = 0.045），低剂量组降低率为18.95%，高剂量组降低率为33.62%。干预3个月后，与安慰剂组和基线水平相比，低剂量组（p = 0.016）和高剂量组（p = 0.0005）尿FB1均显著降低，低剂量组降低率为40.18%，高剂量组降低率为52.6%。GTP处理也显著降低了尿鞘氨酸（Sa）、鞘氨酸（So）和Sa/So比值，但对血清Sa、So和Sa/So比值无影响。混合效应模型分析显示，时间和GTP治疗效果对尿游离FB1水平和Sa/So比值有显著的相互作用。
Green tea polyphenols (GTP) are highly effective in inhibiting a variety of tumorigenic effects induced by carcinogens. In this study we assessed GTP mitigation on biomarkers of fumonisin B1 (FB1), a class 2B carcinogen, in blood and urine samples collected from an intervention trial. A total of 124 exposed people were recruited and randomly assigned to low-dose (GTP 500 mg, n = 42), high-dose (GTP 1,000 mg, n = 41) or placebo (n = 41) for 3 months. After one-month of intervention, urinary FB1 was significantly decreased in high-dose group compared to that of placebo group (p = 0.045), with reduction rates of 18.95% in the low-dose group and 33.62% in the high-dose group. After three-month intervention, urinary FB1 showed significant decrease in both low-dose (p = 0.016) and the high-dose (p = 0.0005) groups compared to that of both placebo group and baseline levels, with reduction rates of 40.18% in the low-dose group and 52.6% in the high-dose group. GTP treatment also significantly reduced urinary excretion of sphinganine (Sa), sphingosine (So), and Sa/So ratio, but had no effect on serum Sa, So, and Sa/So ratio. Analysis with mixed-effect model revealed significant interactions between time and treatment effects of GTP on both urinary free FB1 levels and Sa/So ratios.