Predictive factors for latent tuberculosis infection among adolescents in a high-burden area in South Africa.
Predictive factors for latent tuberculosis infection among adolescents in a high-burden area in South Africa.
复制标题
南非高负担地区青少年潜伏性结核感染的预测因素。
DOI：
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发表时间：
2011
期刊：
影响因子：
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通讯作者：
G. Hussey
中科院分区：
文献类型：
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作者：
H. Mahomed;T. Hawkridge;S. Verver;L. Geiter;M. Hatherill;D. Abrahams;R. Ehrlich;W. Hanekom;G. Hussey
设置
南非结核病(TB)负担高的地区(所有结核病病例的报告率为每10万 000人口1400例)。
客观化
目的：确定青少年潜在结核病感染的患病率及相关预测因素。
设计
从高中招募12-18岁的青少年，收集临床和人口学数据，并进行结核菌素皮肤试验(TST)和Quantiferon®-TB金试管(QFT)试验。
结果
在这些学校的10名 942名青少年中，共有6 363名(58.2%)入学。排除后，在5 244名参与者中，55.2%(95%可信区间53.8~56.5)的≥为5 mm，而50.9%(49.5~52.2)为QFT阳性。在多因素分析中，黑人/混合种族、男性、高龄、家庭接触结核病、低收入和低教育水平是TST和QFT阳性结果的预测因素。
结论
大约一半的青少年被发现在结核病负担高的地区潜伏感染结核病，人口和贫困相关的社会经济因素预测了结核病感染的风险。来自贫困社区的青少年应被视为高负担环境下结核病控制方案教育干预的重要目标群体。
SETTING
A high tuberculosis (TB) burden area in South Africa (notification rate for all TB cases 1400 per 100 000 population).
OBJECTIVE
To determine the prevalence of and predictive factors associated with latent TB infection in adolescents.
DESIGN
Adolescents aged 12-18 years were recruited from high schools, clinical and demographic data were collected, and a tuberculin skin test (TST) and a QuantiFERON®-TB Gold In-Tube (QFT) assay performed.
RESULTS
A total of 6363 (58.2%) of 10 942 adolescents at the schools were enrolled. After exclusions, of 5244 participants, 55.2% (95%CI 53.8-56.5) had TST ≥ 5 mm, while 50.9% (49.5-52.2) were QFT-positive. On multivariate analysis, Black/mixed race racial groups, male sex, older age, household TB contact, low income and low education level were predictive factors for both TST- and QFT-positive results.
CONCLUSION
About half of the adolescents were found to be latently infected with TB in a high TB burden area with demographic and poverty-related socio-economic factors predicting the risk of TB infection. Adolescents from deprived communities should be considered an important target group for educational interventions by TB control programmes in high-burden settings.