Sleep Facilitates Memory by Blocking Dopamine Neuron-Mediated Forgetting.
Sleep Facilitates Memory by Blocking Dopamine Neuron-Mediated Forgetting.
复制标题
睡眠通过阻止多巴胺神经元介导的遗忘来促进记忆。
DOI：
10.1016/j.cell.2015.05.027
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发表时间：
2015-06-18
期刊：
影响因子：
64.5
通讯作者：
Davis RL
中科院分区：
文献类型：
--
作者：
Berry JA;Cervantes-Sandoval I;Chakraborty M;Davis RL
心理学的早期研究表明，睡眠通过阻止由精神活动或外部感官刺激引起的持续的回溯干扰来促进记忆保持。另一方面，对动物模型的神经科学研究表明，睡眠通过增强记忆巩固来促进记忆力。最近在果蝇中，特定多巴胺神经元的持续活动被证明可以调节嗅觉记忆的遗忘。在这里，我们表明这种正在进行的多巴胺能活动与行为状态调制，增加强劲的运动活动和减少休息。增加睡眠驱动，无论是睡眠促进剂加波沙朵或通过遗传刺激的神经回路的睡眠，减少正在进行的多巴胺能活动，同时增强记忆力。相反，增加唤醒刺激持续的多巴胺能活动，并加速基于多巴胺能的遗忘。因此，遗忘受基于多巴胺能的可塑性的行为状态调节。我们的发现整合了心理学和神经科学对睡眠和遗忘的研究。
Early studies from psychology suggest that sleep facilitates memory retention by stopping ongoing retroactive interference caused by mental activity or external sensory stimuli. Neuroscience research with animal models, on the other hand, suggests that sleep facilitates retention by enhancing memory consolidation. Recently in Drosophila, the ongoing activity of specific dopamine neurons was shown to regulate the forgetting of olfactory memories. Here we show this ongoing dopaminergic activity is modulated with behavioral state, increasing robustly with locomotor activity and decreasing with rest. Increasing sleep-drive, with either the sleep-promoting agent Gaboxadol or by genetic stimulation of the neural circuit for sleep, decreases ongoing dopaminergic activity, while enhancing memory retention. Conversely, increasing arousal stimulates ongoing dopaminergic activity and accelerates dopaminergic based forgetting. Therefore, forgetting is regulated by the behavioral state modulation of dopaminergic-based plasticity. Our findings integrate psychological and neuroscience research on sleep and forgetting.