A locus for eosinophilia in the MES rat is on Chromosome 19
A locus for eosinophilia in the MES rat is on Chromosome 19
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DOI：
10.1007/s00335-004-2454-5
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发表时间：
2005-07-01
期刊：
影响因子：
2.5
通讯作者：
Mori, M
中科院分区：
文献类型：
--
作者：
Li, GX;Guo, ZJ;Mori, M
松本氏嗜酸性粒细胞增多症新生大鼠(MatSumoto Eosinophilia Shinshu，MES)是一种自发性地在许多器官中发生嗜酸性粒细胞增多症和嗜酸性粒细胞相关炎症损害的大鼠品系。我们通过选育回交后代，对嗜酸性粒细胞增多症基因进行了染色体定位。与MES相比，回交后代出现嗜酸性粒细胞增多的时间较晚，12周龄回交后代的Eos增多率为22.5%。遗传连锁分析表明，嗜酸性粒细胞增多症的主效基因座位于19号染色体Q臂末端(位于D19Rat8和端粒之间)。该基因座命名为嗜酸性粒细胞增多症I(Eos1)。这些数据将成为利用反向遗传方法鉴定eos1基因的基础，这将有望有助于阐明嗜酸性粒细胞增多症和嗜酸性粒细胞生成的机制。
Matsumoto Eosinophilia Shinshu (MES) is a rat strain that spontaneously develops eosinophilia and eosinophil-related inflammatory lesions in many organs. We performed chromosomal mapping of the gene for eosinophilia by breeding backcross progeny. The onset of eosinophilia appeared to be delayed in the progeny compared with that in MES, with the prevalence of eosinophilia in the backcross progeny at 12 weeks of age being 22.5%. Genetic linkage analysis with marker loci indicated the major locus for eosinophilia was located at the end of the q arm region of Chromosome 19 (between D19Rat8 and telomere). The locus was denoted eosinophilia I (eos1). These data will form the basis for identification of the eos1 gene using a reverse genetic approach, which will hopefully lead to elucidation of the mechanisms involved in eosinophilia and eosinophilopoiesis.