Proton MR spectroscopic changes in Parkinson's diseases after thalamotomy
Proton MR spectroscopic changes in Parkinson's diseases after thalamotomy
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DOI：
10.1016/s0720-048x(02)00211-5
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发表时间：
2003-09-01
影响因子：
3.3
通讯作者：
Suh, TS
中科院分区：
文献类型：
--
作者：
Baik, HM;Choe, BY;Suh, TS
To investigate whether there are significant changes in regional brain metabolism in patients with Parkinson's disease before and after thalamotomy using proton magnetic resonance spectroscopy (H-1 MRS). Fifteen patients underwent 15 stereotactic thalamotomies for control of medically refractory parkinsonian tremor. Single-voxel H-1 MRS was carried out on a 1.5 T unit using stimulated-echo acquisition mode (STEAM) sequence (TR/TM/TE, 2000/14/20 ms). Spectra were obtained from substantia nigra, thalamus and putamen areas with volumes of interests (7-8 ml) in patients before and after the surgery. Metabolite ratios of NAA/Cho, NAA/Cr and Cho/Cr were calculated from relative peak area measurements. We evaluated alterations of metabolite ratios in brain metabolism in Parkinson's disease patients with clinical outcome following thalamotomy. NAA/Cho ratios showed generally low levels in substantia nigra and thalamus in Parkinson's disease patients with clinical improvement following thalamotomy. In 80% (12/15) patients, decreased NAA/Cho ratios were observed from the selected voxels in substantia nigra after thalamic surgery (P < 0.05). The ratios were also significantly decreased in thalamus in 67% (10/15) patients with clinical improvement (P < 0.05). Our results suggest that NAA/Cho ratio may be a valuable criterion for evaluation of Parkinson's disease patients with the clinical improvement following surgery. 1H MRS may be a useful utility for the aid in better understanding the pathophysiologic process in Parkinson's disease patients on the basis of the variation of NAA/Cho ratio. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
