Impaired renal function in a rural Ugandan population cohort.
Impaired renal function in a rural Ugandan population cohort.
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DOI：
10.12688/wellcomeopenres.14863.1
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发表时间：
2018-01-01
影响因子：
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通讯作者：
Newton, Robert
中科院分区：
文献类型：
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作者：
Kalyesubula, Robert;Hau, Jeffrey P;Newton, Robert
背景：慢性肾脏病（CKD）是全球发病率和死亡率的重要原因。然而，关于撒哈拉以南非洲肾功能受损患病率的数据有限。我们的目的是确定慢性肾脏病的患病率和相关因素在乌干达农村人口。方法：我们进行了一项研究，在乌干达西南部的一般人群队列的代表性样本。我们系统地收集了心血管疾病危险因素、人体测量和血红蛋白、HIV、HbA 1c、乙型肝炎B和丙型肝炎以及血清肌酐的血液检测数据。使用CKD-Epi公式计算估计的肾小球滤过率（eGFR），公式中不含人种成分。结果：共有5，979/6，397（93.5%）名参与者具有有效的肌酐结果。平均年龄为39岁（范围：16-103岁），3，627例（60.7%）为女性。艾滋病毒感染率为9.7%，约40%的人口处于高血压前期或高血压。平均血清肌酐水平为0.75 mg/dl（95% CI 0.74-0.75），平均eGFR为109.3 ml/min/1.73 m2（95% CI 108.8-109.9）。CKD的总体患病率（eGFR
Background: Chronic kidney disease (CKD) is an important cause of morbidity and mortality globally. However, there are limited data on the prevalence of impaired kidney function in sub-Saharan Africa. We aimed to determine the prevalence of CKD and associated factors in a rural Ugandan population. Methods: We undertook a study of a representative sample of the General Population Cohort in South-western Uganda. We systematically collected data on cardiovascular disease risk factors, anthropometric measurements and blood tests for haemoglobin, HIV, HbA1c, Hepatitis B and C and serum creatinine. The estimated glomerular filtration rate (eGFR) was calculated using the CKD-Epi formula, without the race component of the equation. Results: A total of 5,979/6,397 (93.5%) participants had valid creatinine results. The mean age was 39 years (Range: 16-103 years) and 3,627 (60.7%) were female. HIV prevalence was 9.7% and about 40% of the population were pre-hypertensive or hypertensive. The mean serum creatinine level was 0.75 mg/dl (95% CI 0.74-0.75), and the average eGFR was 109.3 ml/min/1.73 m 2 (95% CI 108.8-109.9). The overall prevalence of CKD (eGFR