Human immunodeficiency virus types 1 and 2 exhibit comparable sensitivities to Zidovudine and other nucleoside analog inhibitors in vitro.
Human immunodeficiency virus types 1 and 2 exhibit comparable sensitivities to Zidovudine and other nucleoside analog inhibitors in vitro.
复制标题
人类免疫缺陷病毒 1 型和 2 型在体外对齐多夫定和其他核苷类似物抑制剂表现出相当的敏感性。
DOI：
10.1128/aac.01004-07
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发表时间：
2008
影响因子：
4.9
通讯作者：
Preston,BradleyD
中科院分区：
文献类型：
--
作者：
Smith,RobertA;Gottlieb,GeoffreyS;Anderson,DonovanJ;Pyrak,CrystalL;Preston,BradleyD
Using an indicator cell assay that directly quantifies viral replication, we show that human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2, respectively) exhibit similar sensitivities to 3′-azido-3′-deoxythymidine (zidovudine) as well as other nucleoside analog inhibitors of reverse transcriptase. These data support the use of nucleoside analogs for antiviral therapy of HIV-2 infection.
