Decoupling of the amygdala to other salience network regions in adolescent-onset recurrent major depressive disorder.
Decoupling of the amygdala to other salience network regions in adolescent-onset recurrent major depressive disorder.
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DOI：
10.1017/s0033291715002615
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发表时间：
2016-04
影响因子：
6.9
通讯作者：
Langenecker SA
中科院分区：
文献类型：
--
作者：
Jacobs RH;Barba A;Gowins JR;Klumpp H;Jenkins LM;Mickey BJ;Ajilore O;Peciña M;Sikora M;Ryan KA;Hsu DT;Welsh RC;Zubieta JK;Phan KL;Langenecker SA
最近对严重抑郁障碍(MDD)的静息状态网络的荟萃分析表明，疾病的认知和情感特征下的网络中断。到目前为止，研究结果的异质性可能源于相对缺乏分析MDD临床特征的数据，如疾病阶段和多个发作的负担。17例活动期MDD患者和34例缓解期MDD患者和26例健康对照(HCS)的静息状态功能磁共振成像数据跨两个部位收集。参与者没有服用药物，并进一步细分为单次与多次发作的患者，以检查疾病负担。使用后扣带回(PCC)种子探测默认模式网络，以及杏仁核和亚膝前扣带皮质(SgACC)种子探测显著网络(SN)，进行基于种子的连接。与HCS相比，缓解期MDD患者的左侧PCC与左侧额下回、左侧sgACC与右侧前额叶腹内侧皮质(PFC)和左侧海马区的连通性较高。在左侧PCC和右侧PFC背外侧之间，以及左侧杏仁核与右侧脑岛和尾状核之间观察到非事件相关的效应，而多个发作的负荷与左侧PCC与多个认知控制区的低连接以及杏仁核与SN大部分的低连接有关。这是第一次对有青春期MDD病史的未服用药物的年轻人进行同质样本的研究，说明了疾病的基于大脑的发作特征。
Recent meta-analyses of resting-state networks in major depressive disorder (MDD) implicate network disruptions underlying cognitive and affective features of illness. Heterogeneity of findings to date may stem from the relative lack of data parsing clinical features of MDD such as phase of illness and the burden of multiple episodes. Resting-state functional magnetic resonance imaging data were collected from 17 active MDD and 34 remitted MDD patients, and 26 healthy controls (HCs) across two sites. Participants were medication-free and further subdivided into those with single v. multiple episodes to examine disease burden. Seed-based connectivity using the posterior cingulate cortex (PCC) seed to probe the default mode network as well as the amygdala and subgenual anterior cingulate cortex (sgACC) seeds to probe the salience network (SN) were conducted. Young adults with remitted MDD demonstrated hyperconnectivity of the left PCC to the left inferior frontal gyrus and of the left sgACC to the right ventromedial prefrontal cortex (PFC) and left hippocampus compared with HCs. Episode-independent effects were observed between the left PCC and the right dorsolateral PFC, as well as between the left amygdala and right insula and caudate, whereas the burden of multiple episodes was associated with hypoconnectivity of the left PCC to multiple cognitive control regions as well as hypoconnectivity of the amygdala to large portions of the SN. This is the first study of a homogeneous sample of unmedicated young adults with a history of adolescent-onset MDD illustrating brain-based episodic features of illness.