Symposium on Heart Disease. II. Coronary heart disease in the Framingham study
Symposium on Heart Disease. II. Coronary heart disease in the Framingham study
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DOI：
10.2105/ajph.47.4_pt_2.4
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发表时间：
1957-01-01
期刊：
影响因子：
--
通讯作者：
MANN, G. V.
中科院分区：
文献类型：
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作者：
DAWBER, T. R.;MOORE, F. E.;MANN, G. V.
本研究涉及1950年1月1日在马萨诸塞州的Fracket，对年龄在30至59岁之间的人群的心血管疾病的程度和发展进行测量，以及对与心血管疾病的后续出现和进展相关的那些环境和个人因素的研究。本报告涵盖了研究头4年期间的动脉粥样硬化性心脏病，并提出了其他重要调查结果，其中数据表明：动脉粥样硬化性心脏病与吸烟的关系不如与血压、相对体重和胆固醇升高的关系那么密切;动脉粥样硬化性心脏病在男性中的流行率约为女性的两倍;在首次检查后发生的心肌梗死中，约20%无症状;在45至62岁的男性中，高血压和高血压心血管疾病的存在与新的ASHD的发展密切相关;肥胖与45至62岁男性的ASHD发展有关;这似乎可以用肥胖与高血压的关系来解释;高脂血症与45至62岁男性的ASHD发展密切相关;使用3个综合因素（血压、相对体重和血清胆固醇）将45 - 62岁的男性分成具有高度不同的ASHD风险的组。|| 摘要作者：M.弗罗比舍
This study is concerned with measurements of extent and development of cardiovascular disease in a cross-section of population who were aged 30 to 59 on Jan. 1, 1950, in Framingham, Mass., and with study of those environmental and personal factors associated with subsequent appearance and progression of cardiovascular diseases. The present report covers arteriosclerotic heart disease (ASHD) during the first 4 years of the study and presents, among other important findings, data indicating that: association of ASHD with smoking is not as strong as that shown with elevated blood pressure, relative weight, and cholesterol; ASHD was about twice as prevalent in men as in women; about 20% of myocardial infarctions occurring after first examination were asymptomatic; among men aged 45 to 62 presence of high blood pressure and hypertensive cardiovascular disease were strongly associated with development of new ASHD; fatness is associated with development of ASHD in men aged 45 to 62; much of this appeared to be explained by association of obesity with high blood pressure; hypercholesteremia was strongly associated with development of ASHD in men 45 to 62; use of 3 combined factors (blood pressure, relative weight and serum cholesterol) permitted separation of men 45 to 62 into groups with highly divergent risks of ASHD. || ABSTRACT AUTHORS: M. Frobisher