Usefulness of S100P in diagnosis of adenocarcinoma of pancreas on fine-needle aspiration biopsy specimens
Usefulness of S100P in diagnosis of adenocarcinoma of pancreas on fine-needle aspiration biopsy specimens
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DOI：
10.1309/5d76nde81le8g545
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发表时间：
2008-01-01
影响因子：
3.5
通讯作者：
Lin, Fan
中科院分区：
文献类型：
--
作者：
Deng, Hongbing;Shi, Jianhui;Lin, Fan
尽管细针穿刺活检（FNAB）标本中胰腺导管腺癌（PDA）的细胞学标准已经明确，但诊断上的挑战仍然存在。我们用免疫组织化学方法评估了58例胰腺FNAB标本中S100P对细胞阻滞和/或涂片制剂的诊断价值。58例患者分为4组：PDA 1 32例；2,6例诊断不典型或“可疑”；3、良性或反应性导管上皮14例；1组和2组均有S100P阳性免疫反应，而3组14例中只有1例S100P阳性，4组均为S100P阴性。S100P是细胞块和涂片制剂上FNAB标本上检测PDA的敏感特异性标志物。
Even though the cytologic criteria for pancreatic ductal adenocarcinoma (PDA) on fine-needle aspiration biopsy (FNAB) specimens have been well defined, a diagnostic challenge is still present. We immunohistochemically evaluated the diagnostic value of S100P on cell-block and/or smear preparations in 58 cases of FNAB specimens of the pancreas. The 58 cases were divided into 4 groups: 1, 32 cases of PDA; 2, 6 cases with an atypical or "suspicious" diagnosis; 3, 14 cases of benign or reactive ductal epithelium; and 4, 6 cases of endocrine tumor Positive immunoreactivity for S100P was observed in all cases in groups I and 2, whereas only I of 14 cases in group 3 was positive for S100P All cases in group 4 were negative for S100P S100P is a sensitive and specific marker for the detection of PDA on FNAB specimens on cell-block and smear preparations.