DEVELOPMENT AND DEGENERATION OF RETINA IN RDS MUTANT MICE - THE ELECTRORETINOGRAM
DEVELOPMENT AND DEGENERATION OF RETINA IN RDS MUTANT MICE - THE ELECTRORETINOGRAM
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DOI：
10.1016/0304-3940(84)90024-7
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发表时间：
1984-01-01
影响因子：
2.5
通讯作者：
SANYAL, S
中科院分区：
文献类型：
--
作者：
REUTER, JH;SANYAL, S
在小鼠中，纯合子视网膜变性慢（rds）基因，光感受器细胞缺乏外节盘状结构，含有少量视紫红质，变性缓慢，而视网膜内层保持完整。1个月视网膜电图。-老龄突变小鼠的振幅低于正常，但峰值时间正常。2-3岁和6-7岁突变小鼠的ERG反应幅度进一步下降，受体细胞群随着退化的进展而减少，而到达峰值的时间增加。1岁的突变小鼠完全失去了受体细胞，因此没有ERG。讨论了rds突变小鼠ERG及其组分可能的形态学相关性。
In mice, homozygous for the retinal degeneration slow (rds) gene, the photoreceptor cells lack outer segment disc structures, contain low amounts of rhodopsin, and degenerative slowly, while the inner retinal layers remain intact. The electroretinogram (ERG) from 1-mo.-old mutant mice shows a lower than normal amplitude but the time-to-peak is normal. The ERG from mutant mice of 2-3 mo. and 6-7 mo. of age show a further decline in response amplitude as the receptor cell population is depleted with progress of degeneration while the time-to-peak increases. The ERG is absent in 1-yr-old mutant mice which have lost their receptor cells completely. The possible morphological correlations of the ERG and its components in the rds mutant mice are discussed.