Sex Differences in the Evolution of Neutralizing Antibodies to Severe Acute Respiratory Syndrome Coronavirus 2
Sex Differences in the Evolution of Neutralizing Antibodies to Severe Acute Respiratory Syndrome Coronavirus 2
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DOI：
10.1093/infdis/jiab127
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发表时间：
2021-08-12
影响因子：
6.4
通讯作者：
Fafi-Kremer, Samira
中科院分区：
文献类型：
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作者：
Grzelak, Ludivine;Velay, Aurelie;Fafi-Kremer, Samira
我们测量了308名医护人员血清中的抗刺突（S），核蛋白（N）和中和抗体，这些医护人员具有严重急性呼吸综合征冠状病毒2型的阳性逆转录定量聚合酶链反应结果，并且患有轻度疾病，在症状发作后的2个时间点收集长达6个月。在第1个月，年龄>50岁的男性参与者和体重指数（BMI）>25 kg/m2的参与者的抗S和抗N抗体水平较高。在3-6个月，分别在99%和59%的个体中检测到抗S和抗N抗体。抗S抗体和中和抗体下降速度男性比女性，独立的年龄和BMI，这表明性别与体液反应的演变。
We measured anti-spike (S), nucleoprotein (N), and neutralizing antibodies in sera from 308 healthcare workers with a positive reverse-transcription quantitative polymerase chain reaction result for severe acute respiratory syndrome coronavirus 2 and with mild disease, collected at 2 timepoints up to 6 months after symptom onset. At month 1, anti-S and -N antibody levels were higher in male participants aged >50 years and participants with a body mass index (BMI) >25 kg/m(2). At months 3-6, anti-S and anti-N antibodies were detected in 99% and 59% of individuals, respectively. Anti-S antibodies and neutralizing antibodies declined faster in men than in women, independent of age and BMI, suggesting an association of sex with evolution of the humoral response.