Silica monolithic membrane as separation medium. Summable property of different membranes for high-performance liquid chromatographic separation.
Silica monolithic membrane as separation medium. Summable property of different membranes for high-performance liquid chromatographic separation.
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DOI：
10.1016/j.chroma.2004.09.042
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发表时间：
2005-05
期刊：
影响因子：
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通讯作者：
K. Hosoya;T. Ogata;Y. Watabe;T. Kubo;T. Ikegami;N. Tanaka;H. Minakuchi;K. Nakanishi
中科院分区：
文献类型：
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作者：
K. Hosoya;T. Ogata;Y. Watabe;T. Kubo;T. Ikegami;N. Tanaka;H. Minakuchi;K. Nakanishi
研究了硅胶单片膜作为高效液相色谱（HPLC）分离介质的适用性。我们制备了具有三维网状结构的多孔硅单片膜，并将其切割成型为膜分离介质。我们用高效液相色谱法评价了多种溶质的色谱性质，以阐明膜分离介质的可求和性质。此外，我们还对将具有不同表面特征的膜堆叠在一柱（即膜柱）中分离全血中HbA1c进行了简单的研究。我们证实膜柱在一定程度上能够将HbA1c从全血中的其他基质中分离出来，并且具有优异的疏水和离子交换吸附能力。
We studied an applicability of a silica monolithic membrane as separation medium for high-performance liquid chromatography (HPLC). We prepared porous monolithic silica membranes having a three-dimensional network structure to cut and shape into a membrane separation medium. We evaluated chromatographic properties of a variety of solutes using a column containing the membranes with HPLC to elucidate summable property of the membrane separation media. In addition, we made brief study on separation of HbA1c in whole blood with the stacked" membranes having different surface characteristics in one column, which is a membrane column. We confirmed that the membrane column was able to separate HbA1c from other matrix in whole blood to some extent, and it also had an excellent ability for hydrophobic and ion exchange adsorption.