CONTROLLED SEDATION WITH ALPHAXALONE-ALPHADOLONE
CONTROLLED SEDATION WITH ALPHAXALONE-ALPHADOLONE
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DOI：
10.1136/bmj.2.5920.656
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发表时间：
1974-01-01
影响因子：
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通讯作者：
GOODWIN, R
中科院分区：
文献类型：
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作者：
RAMSAY, MAE;SAVEGE, TM;GOODWIN, R
阿法沙龙-曲马多龙（Althesin），稀释和管理作为控制输注，被用作镇静剂的30例患者在强化治疗单位。这种技术可以快速准确地控制镇静水平。它有三个特别有用的应用：它提供了“浅睡眠”，允许快速变化的镇静水平，并使中枢神经系统的重复评估。镇静是令人满意的总时间的86%，没有严重的并发症归因于使用该药物。此外，尽管阿法沙龙-曲马多龙给药长达20天，但没有快速耐受或恢复时间延迟的证据。
Alphaxalone-alphadolone (Althesin), diluted and administered as a controlled infusion, was used as a sedative for 30 patients in an intensive therapy unit. This technique allowed rapid and accurate control of the level of sedation. It had three particularly useful applications: it provided “light sleep,” allowed rapid variation in the level of sedation, and enabled repeated assessment of the central nervous system.Sedation was satisfactory for 86% of the total time, and no serious complications were attributed to the use of the drug. Furthermore, though alphaxalone-alphadolone was given for periods up to 20 days there was no evidence of tachyphylaxis or delay in recovery time.