Serum dioxin level in relation to diabetes mellitus among Air Force Veterans with background levels of exposure
Serum dioxin level in relation to diabetes mellitus among Air Force Veterans with background levels of exposure
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DOI：
10.1097/00001648-200001000-00010
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发表时间：
2000-01-01
期刊：
影响因子：
5.4
通讯作者：
Michalek, JE
中科院分区：
文献类型：
--
作者：
Longnecker, MP;Michalek, JE
几项流行病学研究的数据表明，暴露于异常高含量的二恶英（2，3，7，8-四氯二苯并对二恶英）会增加患糖尿病的风险，实验数据表明，其机制是细胞葡萄糖摄取减少。为了更密切地研究剂量反应关系，我们研究了血清二恶英水平与糖尿病患病率以及血清胰岛素和葡萄糖水平之间的关系，空军健康研究中的197名退伍军人从未接触过二恶英污染的除草剂，其血清二恶英水平在美国常见的背景暴露范围内（小于或等于10纳克/千克脂质）。与血清二恶英水平在第一四分位数的受试者相比（
Data from several epidemiologic studies suggest that exposure to unusually high amounts of dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin) increases the risk of diabetes mellitus, and experimental data suggest that the mechanism for this is decreased cellular glucose uptake. To investigate the dose-response relation more closely, we examined the association of serum dioxin level with prevalence of diabetes mellitus and with levels of serum insulin and glucose among 1,197 veterans in the Air Force Health Study who never had contact with dioxin-contaminated herbicides and whose serum dioxin level was within the range of background exposure typically seen in the United States (less than or equal to 10 ng/kg lipid). Compared with those whose serum dioxin level was in the first quartile (