EFFECTS OF COCAINE AND ALCOHOL-USE IN PREGNANCY ON NEONATAL GROWTH AND NEUROBEHAVIORAL STATUS
EFFECTS OF COCAINE AND ALCOHOL-USE IN PREGNANCY ON NEONATAL GROWTH AND NEUROBEHAVIORAL STATUS
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DOI：
10.1016/0892-0362(92)90025-6
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发表时间：
1992-01-01
影响因子：
2.9
通讯作者：
FALEK, A
中科院分区：
文献类型：
--
作者：
COLES, CD;PLATZMAN, KA;FALEK, A
研究了怀孕期间使用可卡因和酒精对胎儿生长和新生儿行为的影响，研究对象是低收入、以黑人为主的妇女所生的婴儿。尽管孕妇使用可卡因的情况有所增加，并引起公众的关注，但对接触可卡因的新生儿的行为研究在数量和范围上都很有限。在大多数研究中，混杂因素（例如多种药物滥用、早产、婴儿健康状况）没有得到控制，因此可卡因和其他药物接触的实际影响尚不清楚。因此，本研究调查了产前药物暴露的影响，但通过实验控制了已知与婴儿不良结局相关的其他因素：早产、其他非法药物使用、相关疾病（例如性传播疾病[STDs]）和药物使用时间。此外，统计控制的其他因素有：实验者效应、评估时间、可卡因、酒精、大麻和尼古丁暴露的持续时间、数量和频率的影响。本研究采用Brazelton新生儿行为评估量表（BNBAS）对107名足月婴儿进行了2、14和28天的评估。生长因子（即出生体重、体长、头围）也进行了评估。
Effects on fetal growth and neonatal behavior of cocaine and alcohol use in pregnancy were investigated in infants born to women in a low-income, predominantly black population. Despite the increased use of cocaine by pregnant women and the accompanying public concern, behavioral studies of exposed neonates are limited in number and scope. In most studies, confounding factors (e.g., polydrug abuse, prematurity, infant health status) have not been controlled so the actual effects of cocaine and other drug exposure are not clear. Accordingly, this study investigated effects of prenatal drug exposure although controlling experimentally for other factors known to be associated with poor outcomes in infants: prematurity, other illicit drug use, associated diseases (e.g., sexually transmitted diseases [STDs]), and duration of drug use. In addition, other factors statistically controlled were: experimenter effects, timing of assessment, and effects of duration, amount, and frequency of cocaine, alcohol, marijuana, and nicotine exposure.One hundred and seven full-term infants were assessed at 2, 14, and 28 days using the Brazelton Neonatal Behavioral Assessment Scale (BNBAS) by testers blind to infant status. Growth factors (i.e., birthweight, length, head circumference) were also assessed.