Conjugated linoleic acid depresses the 9 desaturase index and stearoyl coenzyme A desaturase enzyme activity in porcine subcutaneous adipose tissue
Conjugated linoleic acid depresses the 9 desaturase index and stearoyl coenzyme A desaturase enzyme activity in porcine subcutaneous adipose tissue
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发表时间：
2002
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通讯作者：
S. B. Smith;T. S. Hively;G. Cortese;J. Han;K. Chung;P. Casteñada;C. D. Gilbert;V. L. Adams;H. Mersmann
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作者：
S. B. Smith;T. S. Hively;G. Cortese;J. Han;K. Chung;P. Casteñada;C. D. Gilbert;V. L. Adams;H. Mersmann
共轭亚油酸 (CLA) 已被证明对皮下脂肪酸组成有影响，并且据报道可以通过降低啮齿动物和啮齿动物细胞系中的 mRNA 表达和（或）催化活性来降低硬脂酰辅酶 A 去饱和酶 (SCD) 活性。本研究旨在研究 CLA、玉米油或牛脂补充剂对皮下脂肪组织的影响。仔猪脂肪组织脂肪酸组成、肥胖度、SCD酶活性和9种去饱和酶指数。 18 只 16 至 18 天龄的杂交小公猪适应饮食 1 周，然后随机分配至三种处理之一：添加 1.5% CLA、添加 1.5% 玉米油或添加 1.5% 牛脂。阉猪单独圈养并饲喂补充油 35 天（至 25.6 ± 0.6 kg 体重）。皮下脂肪组织样本是在以下情况下获得的：
Conjugated linoleic acid (CLA) has been shown to have an effect on subcutaneous fatty acid composition and has been reported to decrease stearoyl coenzyme A desaturase (SCD) activity by decreasing mRNA expression and(or) catalytic activity in rodents and rodent cell lines. This investigation was designed to study the effects of CLA, corn oil, or beef tallow supplementation on s.c. adipose tissue fatty acid composition, adiposity, SCD enzyme activity, and the 9 desaturase index in piglets. Eighteen crossbred barrows 16 to 18 d of age were adapted to diet for 1 wk and then assigned randomly to one of three treatments: 1.5% added CLA, 1.5% added corn oil, or 1.5% added beef tallow. Barrows were penned individually and fed the supplemental oils for 35 d (to 25.6 ± 0.6 kg BW). Subcutaneous adipose tissue samples were obtained after