Optical biopsy of breast tissue using differential path-length spectroscopy
Optical biopsy of breast tissue using differential path-length spectroscopy
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DOI：
10.1088/0031-9155/50/11/009
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发表时间：
2005-06-07
影响因子：
3.5
通讯作者：
Sterenborg, HJCM
中科院分区：
文献类型：
--
作者：
van Veen, RLP;Amelink, A;Sterenborg, HJCM
Differential path-length spectroscopy (DPS) was used to determine the local optical properties of breast tissue in vivo. DPS measurements were made on healthy and malignant breast tissue using a fibre-optic needle probe, and were correlated to the histological outcome of core-needle biopsies taken from the same location as the measurements. DPS yields information on the local tissue blood content, the local blood oxygenation, the average micro-vessel diameter, the beta-carotcne concentration and the scatter slope. Our data show that malignant breast tissue is characterized by a significant decrease in tissue oxygenation and a higher blood content compared to normal breast tissue.
